D-CECaT as preoperative chemotherapy for unresectable neuroblastoma in children over one year of age

A. Donfrancesco, G. Deb, C. Dominici, L. De Sio, A. Inserra, C. Boglino, M. Takahashi, J. Uchino, L. Helson

Research output: Contribution to journalArticlepeer-review

Abstract

The role of intensive pre- and postoperative chemotherapy in unresectable nonmetastatic neuroblastoma is still controversial. A preoperative regimen that included deferoxamine, cyclophosphamide, etoposide, carboplatin and thiotepa (D-CECaT) was evaluated in 10 children over one year of age at diagnosis, and this was followed by surgery and postoperative chemotherapy. After four courses of D-CECaT, the response rate was 9/10 with 3 complete responses, 6 partial responses and 1 minor response. Severe but transitory myelosuppression was the major toxic effect. Complete remission by combined D-CECaT chemotherapy and surgery was obtained in 9/10 patients, while 1 case achieved complete remission only with postoperative chemotherapy. All children are disease-free with a median follow-up of 30.5 months (range: 1+ to 50+). This intensive treatment was effective in both standard- and high-risk unresectable NB. However, whether a less intensive approach and fewer courses can also give similar results in standard-risk cases warrants further study.

Original languageEnglish
Pages (from-to)2347-2350
Number of pages4
JournalAnticancer Research
Volume15
Issue number5 B
Publication statusPublished - 1995

Keywords

  • Carboplatin
  • Cyclophosphamide
  • Deferoxamine
  • Etoposide
  • Neuroblastoma
  • Thiotepa

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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