Abstract
The role of intensive pre- and postoperative chemotherapy in unresectable nonmetastatic neuroblastoma is still controversial. A preoperative regimen that included deferoxamine, cyclophosphamide, etoposide, carboplatin and thiotepa (D-CECaT) was evaluated in 10 children over one year of age at diagnosis, and this was followed by surgery and postoperative chemotherapy. After four courses of D-CECaT, the response rate was 9/10 with 3 complete responses, 6 partial responses and 1 minor response. Severe but transitory myelosuppression was the major toxic effect. Complete remission by combined D-CECaT chemotherapy and surgery was obtained in 9/10 patients, while 1 case achieved complete remission only with postoperative chemotherapy. All children are disease-free with a median follow-up of 30.5 months (range: 1+ to 50+). This intensive treatment was effective in both standard- and high-risk unresectable NB. However, whether a less intensive approach and fewer courses can also give similar results in standard-risk cases warrants further study.
Original language | English |
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Pages (from-to) | 2347-2350 |
Number of pages | 4 |
Journal | Anticancer Research |
Volume | 15 |
Issue number | 5 B |
Publication status | Published - 1995 |
Keywords
- Carboplatin
- Cyclophosphamide
- Deferoxamine
- Etoposide
- Neuroblastoma
- Thiotepa
ASJC Scopus subject areas
- Cancer Research
- Oncology