D-fenfluramine and d-norfenfluramine reduce food intake by acting on different serotonin mechanisms in the rat brain

F. Borsini, C. Bendotti, A. Aleotti, R. Samanin, S. Garattini

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The anorectic effect of d-norfenfluramine, but not that of d-fenfluramine, was potentiated in reserpine-treated rats. Chlorimipramine reduced the effect of d-fenfluramine but not that of d-norfenfluramine. Parachlorophenylalanine and xylamidine, a peripheral serotonin antagonist, unlike metergoline, did not modify the effect of either drug. The data suggest that d-fenfluramine and d-norfenfluramine depress food intake by acting on different serotonin mechanisms in the rat brain.

Original languageEnglish
Pages (from-to)671-678
Number of pages8
JournalPharmacological Research Communications
Volume14
Issue number7
DOIs
Publication statusPublished - 1982

Fingerprint

Norfenfluramine
Fenfluramine
Serotonin
Eating
Brain
Metergoline
Clomipramine
Appetite Depressants
Serotonin Antagonists
Reserpine
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

D-fenfluramine and d-norfenfluramine reduce food intake by acting on different serotonin mechanisms in the rat brain. / Borsini, F.; Bendotti, C.; Aleotti, A.; Samanin, R.; Garattini, S.

In: Pharmacological Research Communications, Vol. 14, No. 7, 1982, p. 671-678.

Research output: Contribution to journalArticle

@article{f3ba215aaec34ba3a429e5f8efc7719d,
title = "D-fenfluramine and d-norfenfluramine reduce food intake by acting on different serotonin mechanisms in the rat brain",
abstract = "The anorectic effect of d-norfenfluramine, but not that of d-fenfluramine, was potentiated in reserpine-treated rats. Chlorimipramine reduced the effect of d-fenfluramine but not that of d-norfenfluramine. Parachlorophenylalanine and xylamidine, a peripheral serotonin antagonist, unlike metergoline, did not modify the effect of either drug. The data suggest that d-fenfluramine and d-norfenfluramine depress food intake by acting on different serotonin mechanisms in the rat brain.",
author = "F. Borsini and C. Bendotti and A. Aleotti and R. Samanin and S. Garattini",
year = "1982",
doi = "10.1016/S0031-6989(82)80025-8",
language = "English",
volume = "14",
pages = "671--678",
journal = "Pharmacological Research",
issn = "1043-6618",
publisher = "Academic Press",
number = "7",

}

TY - JOUR

T1 - D-fenfluramine and d-norfenfluramine reduce food intake by acting on different serotonin mechanisms in the rat brain

AU - Borsini, F.

AU - Bendotti, C.

AU - Aleotti, A.

AU - Samanin, R.

AU - Garattini, S.

PY - 1982

Y1 - 1982

N2 - The anorectic effect of d-norfenfluramine, but not that of d-fenfluramine, was potentiated in reserpine-treated rats. Chlorimipramine reduced the effect of d-fenfluramine but not that of d-norfenfluramine. Parachlorophenylalanine and xylamidine, a peripheral serotonin antagonist, unlike metergoline, did not modify the effect of either drug. The data suggest that d-fenfluramine and d-norfenfluramine depress food intake by acting on different serotonin mechanisms in the rat brain.

AB - The anorectic effect of d-norfenfluramine, but not that of d-fenfluramine, was potentiated in reserpine-treated rats. Chlorimipramine reduced the effect of d-fenfluramine but not that of d-norfenfluramine. Parachlorophenylalanine and xylamidine, a peripheral serotonin antagonist, unlike metergoline, did not modify the effect of either drug. The data suggest that d-fenfluramine and d-norfenfluramine depress food intake by acting on different serotonin mechanisms in the rat brain.

UR - http://www.scopus.com/inward/record.url?scp=0020457087&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020457087&partnerID=8YFLogxK

U2 - 10.1016/S0031-6989(82)80025-8

DO - 10.1016/S0031-6989(82)80025-8

M3 - Article

VL - 14

SP - 671

EP - 678

JO - Pharmacological Research

JF - Pharmacological Research

SN - 1043-6618

IS - 7

ER -