D-Luciferin, derivatives and analogues: Synthesis and in vitro/in vivo luciferase-catalyzed bioluminescent activity

Giuseppe Meroni, Mehdi Rajabi, Enzo Santaniello

Research output: Contribution to journalArticlepeer-review

Abstract

D-luciferin is the natural substrate of all luciferases that catalyze the production of light in bioluminescent insects. The present review covers the synthesis of D-luciferin and derivatives or analogues that are substrates or inhibitors of the luciferase from the American firefly Photinus pyralis, the enzyme more frequently used in techniques of in vitro and optical imaging.

Original languageEnglish
Pages (from-to)265-288
Number of pages24
JournalArkivoc
Volume2009
Issue number1
Publication statusPublished - Feb 21 2009

Keywords

  • Bioluminescence
  • D-luciferin
  • Luciferase
  • Optical imaging
  • Synthesis

ASJC Scopus subject areas

  • Organic Chemistry

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