D-Sorbitol plasma disappearance rate: An index to evaluate changes in liver circulation

Marco Ballarè, Paolo Avagnina, Mauro Torchio, Alberto Cavanna, Patrizia E. Aurucci, Anna G. Niro, Gianpaolo Molino

Research output: Contribution to journalArticlepeer-review


The hepatic clearance of D-sorbitol was proven to be a reliable parameter for evaluating the functional liver plasma flow. Twenty-five normal subjects and 50 cirrhotic patients were studied in order to assess if the measure of the plasma disappearance rate of sorbitol can be used as a simpler procedure to evaluate changes in liver perfusion and to predict modifications of drug bioavailability due to circulatory events. The plasma disappearance rate was calculated between 10 and 20 min after intravenous administration of a 2-g dose because in this time interval plasma levels were in the optimum range for the chemical assay, and the plasma concentration/time curve fitted a decreasing exponential function. Plasma disappearance rate values were found to correlate significantly (r = 0.666, p-1 in cirrhotic patients, and 0.081 ± 0.014 min-1 in normal subjects (p

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalLa Ricerca in Clinica e in Laboratorio
Issue number4
Publication statusPublished - Oct 1988


  • D-sorbitol
  • Hepatic clearance
  • Hepatic removal
  • Liver circulation
  • Portacaval shunt

ASJC Scopus subject areas

  • Clinical Biochemistry


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