D-Sorbitol plasma disappearance rate: An index to evaluate changes in liver circulation

Marco Ballarè, Paolo Avagnina, Mauro Torchio, Alberto Cavanna, Patrizia E. Aurucci, Anna G. Niro, Gianpaolo Molino

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The hepatic clearance of D-sorbitol was proven to be a reliable parameter for evaluating the functional liver plasma flow. Twenty-five normal subjects and 50 cirrhotic patients were studied in order to assess if the measure of the plasma disappearance rate of sorbitol can be used as a simpler procedure to evaluate changes in liver perfusion and to predict modifications of drug bioavailability due to circulatory events. The plasma disappearance rate was calculated between 10 and 20 min after intravenous administration of a 2-g dose because in this time interval plasma levels were in the optimum range for the chemical assay, and the plasma concentration/time curve fitted a decreasing exponential function. Plasma disappearance rate values were found to correlate significantly (r = 0.666, p-1 in cirrhotic patients, and 0.081 ± 0.014 min-1 in normal subjects (p

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalLa Ricerca in Clinica e in Laboratorio
Volume18
Issue number4
DOIs
Publication statusPublished - Oct 1988

Fingerprint

Liver Circulation
Sorbitol
Liver
Plasmas
Plasma flow
Exponential functions
Assays
Intravenous Administration
Biological Availability
Perfusion
Pharmaceutical Preparations

Keywords

  • D-sorbitol
  • Hepatic clearance
  • Hepatic removal
  • Liver circulation
  • Portacaval shunt

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

D-Sorbitol plasma disappearance rate : An index to evaluate changes in liver circulation. / Ballarè, Marco; Avagnina, Paolo; Torchio, Mauro; Cavanna, Alberto; Aurucci, Patrizia E.; Niro, Anna G.; Molino, Gianpaolo.

In: La Ricerca in Clinica e in Laboratorio, Vol. 18, No. 4, 10.1988, p. 305-311.

Research output: Contribution to journalArticle

Ballarè, M, Avagnina, P, Torchio, M, Cavanna, A, Aurucci, PE, Niro, AG & Molino, G 1988, 'D-Sorbitol plasma disappearance rate: An index to evaluate changes in liver circulation', La Ricerca in Clinica e in Laboratorio, vol. 18, no. 4, pp. 305-311. https://doi.org/10.1007/BF02919088
Ballarè, Marco ; Avagnina, Paolo ; Torchio, Mauro ; Cavanna, Alberto ; Aurucci, Patrizia E. ; Niro, Anna G. ; Molino, Gianpaolo. / D-Sorbitol plasma disappearance rate : An index to evaluate changes in liver circulation. In: La Ricerca in Clinica e in Laboratorio. 1988 ; Vol. 18, No. 4. pp. 305-311.
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