D1 agonist CY208-243 attenuates the pattern electroretinogram to low spatial frequency stimuli in the monkey

A. Peppe, A. Antal, M. Tagliati, P. Stanzione, I. Bodis-Wollner

Research output: Contribution to journalArticle

Abstract

We investigated whether or not the D1 agonist, CY 208-243, affects the spatial tuning function of pattern electroretinogram (PERG). Two lightly anaesthetised monkeys were studied before and after CY 208-243 or placebo administration. The results show that the PERG response to 0.5 cycles/degree (c/d; coarse), but not to 2.3 c/d (medium) spatial frequency stimuli disappears following systemic administration of this drug. Since previous results show that D2 blockers attenuate the PERG only above 2.3 c/d, foremost the peak of the normal spatial frequency response function, the current results suggest that dopamine itself, via D1 receptors, may be responsible for the low spatial frequency decline of normal spatial PERG tuning function. We infer that the synergistic activation of D1 and D2 receptors is needed to shape the spatially tuned primate ERG.

Original languageEnglish
Pages (from-to)5-8
Number of pages4
JournalNeuroscience Letters
Volume243
Issue number1-3
DOIs
Publication statusPublished - Feb 27 1998

Keywords

  • D1 agonist
  • Dopamine
  • Monkey
  • Retina
  • Spatial frequencies
  • Tuning function

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'D1 agonist CY208-243 attenuates the pattern electroretinogram to low spatial frequency stimuli in the monkey'. Together they form a unique fingerprint.

Cite this