Daidzein and its effects on brain

Touqeer Ahmed, Sana Javed, Ameema Tariq, Barbara Budzyńska, Grazia D'Onofrio, Maria Daglia, Seyed Fazel Nabavi, Seyed Mohammad Nabavi

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Among naturally occurring isoflavones, soy isoflavones are an important class with various biological activities. Due to their phytoestrogenic structure, their effects on the brain are profound thus making the neurobiological effects of these compounds an active area of research. One such compound is daidzein, which has been reported to affect various neurobiological regulatory mechanisms such as behavior, cognition, growth, development and reproduction. These effects are mainly elicited through the interaction of daidzein with different signaling molecules and receptors, thereby offering neuroprotection. In addition, daidzein has also been reported to possess activities against various neuropathological conditions mainly by its interaction with the cerebrovascular system. This review focuses on providing a comprehensive account on the bioavailability and metabolism of daidzein in vivo, and discusses its activities and mechanisms of action in detail, in both physiological and pathological conditions. In addition, the effects of daidzein on other disorders have also been examined briefly in this article.

Original languageEnglish
Pages (from-to)365-375
Number of pages11
JournalCurrent Medicinal Chemistry
Volume24
Issue number4
DOIs
Publication statusPublished - Feb 1 2017

Fingerprint

Brain
Isoflavones
Bioactivity
Growth and Development
Metabolism
Cognition
Biological Availability
Reproduction
daidzein
Molecules
Research

Keywords

  • Cellular pathways
  • Daidzein
  • Genistein
  • Hormones
  • Neuroprotection

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Ahmed, T., Javed, S., Tariq, A., Budzyńska, B., D'Onofrio, G., Daglia, M., ... Nabavi, S. M. (2017). Daidzein and its effects on brain. Current Medicinal Chemistry, 24(4), 365-375. https://doi.org/10.2174/0929867323666161101140214

Daidzein and its effects on brain. / Ahmed, Touqeer; Javed, Sana; Tariq, Ameema; Budzyńska, Barbara; D'Onofrio, Grazia; Daglia, Maria; Nabavi, Seyed Fazel; Nabavi, Seyed Mohammad.

In: Current Medicinal Chemistry, Vol. 24, No. 4, 01.02.2017, p. 365-375.

Research output: Contribution to journalReview article

Ahmed, T, Javed, S, Tariq, A, Budzyńska, B, D'Onofrio, G, Daglia, M, Nabavi, SF & Nabavi, SM 2017, 'Daidzein and its effects on brain', Current Medicinal Chemistry, vol. 24, no. 4, pp. 365-375. https://doi.org/10.2174/0929867323666161101140214
Ahmed T, Javed S, Tariq A, Budzyńska B, D'Onofrio G, Daglia M et al. Daidzein and its effects on brain. Current Medicinal Chemistry. 2017 Feb 1;24(4):365-375. https://doi.org/10.2174/0929867323666161101140214
Ahmed, Touqeer ; Javed, Sana ; Tariq, Ameema ; Budzyńska, Barbara ; D'Onofrio, Grazia ; Daglia, Maria ; Nabavi, Seyed Fazel ; Nabavi, Seyed Mohammad. / Daidzein and its effects on brain. In: Current Medicinal Chemistry. 2017 ; Vol. 24, No. 4. pp. 365-375.
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