Abstract
Among naturally occurring isoflavones, soy isoflavones are an important class with various biological activities. Due to their phytoestrogenic structure, their effects on the brain are profound thus making the neurobiological effects of these compounds an active area of research. One such compound is daidzein, which has been reported to affect various neurobiological regulatory mechanisms such as behavior, cognition, growth, development and reproduction. These effects are mainly elicited through the interaction of daidzein with different signaling molecules and receptors, thereby offering neuroprotection. In addition, daidzein has also been reported to possess activities against various neuropathological conditions mainly by its interaction with the cerebrovascular system. This review focuses on providing a comprehensive account on the bioavailability and metabolism of daidzein in vivo, and discusses its activities and mechanisms of action in detail, in both physiological and pathological conditions. In addition, the effects of daidzein on other disorders have also been examined briefly in this article.
| Original language | English |
|---|---|
| Pages (from-to) | 365-375 |
| Number of pages | 11 |
| Journal | Current Medicinal Chemistry |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Feb 1 2017 |
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Keywords
- Cellular pathways
- Daidzein
- Genistein
- Hormones
- Neuroprotection
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
Cite this
Daidzein and its effects on brain. / Ahmed, Touqeer; Javed, Sana; Tariq, Ameema; Budzyńska, Barbara; D'Onofrio, Grazia; Daglia, Maria; Nabavi, Seyed Fazel; Nabavi, Seyed Mohammad.
In: Current Medicinal Chemistry, Vol. 24, No. 4, 01.02.2017, p. 365-375.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Daidzein and its effects on brain
AU - Ahmed, Touqeer
AU - Javed, Sana
AU - Tariq, Ameema
AU - Budzyńska, Barbara
AU - D'Onofrio, Grazia
AU - Daglia, Maria
AU - Nabavi, Seyed Fazel
AU - Nabavi, Seyed Mohammad
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Among naturally occurring isoflavones, soy isoflavones are an important class with various biological activities. Due to their phytoestrogenic structure, their effects on the brain are profound thus making the neurobiological effects of these compounds an active area of research. One such compound is daidzein, which has been reported to affect various neurobiological regulatory mechanisms such as behavior, cognition, growth, development and reproduction. These effects are mainly elicited through the interaction of daidzein with different signaling molecules and receptors, thereby offering neuroprotection. In addition, daidzein has also been reported to possess activities against various neuropathological conditions mainly by its interaction with the cerebrovascular system. This review focuses on providing a comprehensive account on the bioavailability and metabolism of daidzein in vivo, and discusses its activities and mechanisms of action in detail, in both physiological and pathological conditions. In addition, the effects of daidzein on other disorders have also been examined briefly in this article.
AB - Among naturally occurring isoflavones, soy isoflavones are an important class with various biological activities. Due to their phytoestrogenic structure, their effects on the brain are profound thus making the neurobiological effects of these compounds an active area of research. One such compound is daidzein, which has been reported to affect various neurobiological regulatory mechanisms such as behavior, cognition, growth, development and reproduction. These effects are mainly elicited through the interaction of daidzein with different signaling molecules and receptors, thereby offering neuroprotection. In addition, daidzein has also been reported to possess activities against various neuropathological conditions mainly by its interaction with the cerebrovascular system. This review focuses on providing a comprehensive account on the bioavailability and metabolism of daidzein in vivo, and discusses its activities and mechanisms of action in detail, in both physiological and pathological conditions. In addition, the effects of daidzein on other disorders have also been examined briefly in this article.
KW - Cellular pathways
KW - Daidzein
KW - Genistein
KW - Hormones
KW - Neuroprotection
UR - http://www.scopus.com/inward/record.url?scp=85016141868&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85016141868&partnerID=8YFLogxK
U2 - 10.2174/0929867323666161101140214
DO - 10.2174/0929867323666161101140214
M3 - Review article
VL - 24
SP - 365
EP - 375
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
SN - 0929-8673
IS - 4
ER -