Daily rapid blood glucose variations may condition antithrombin III biologic activity but not its plasma concentration in insulin-dependent diabetes. A possible role for labile non-enzymatic glycation

A. Ceriello, D. Giugliano, A. Quatraro, A. Stante, G. Consoli, P. Dello Russo, F. D'Onofrio

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of rapid daily variation of glycemia and labile HbA1 on both antithrombin III (ATIII) activity and plasma concentration in ten insulin dependent diabetics has been evaluated. The variations of both plasma glucose and labile HbA1 were inversely correlated to the alterations of ATIII activity (r = -0.71 and r = -0.73, respectively, p <0.001), while no change in ATIII plasma concentration was present. These data suggest a direct role of glucose in determining rapid alteration of ATIII biologic activity, in vivo, in diabetes, probably mediated by labile non-enzymatic glycation.

Original languageEnglish
Pages (from-to)16-19
Number of pages4
JournalDiabete et Metabolisme
Volume13
Issue number1
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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