Abstract
Plasma levels of metyrapone were measured in rats standardized in an alternating 12-hr-light and 12-hr-dark regimen, every 4 hr over a 24-hr period. The results indicate a circadian periodicity with a half-life at 22.00 hr (10 p.m.) which was approximately 2.5-fold longer than that observed at 10.00 hr (10 a.m.).
| Original language | English |
|---|---|
| Pages (from-to) | 2767-2769 |
| Number of pages | 3 |
| Journal | Biochemical Pharmacology |
| Volume | 18 |
| Issue number | 12 |
| Publication status | Published - Dec 1969 |
ASJC Scopus subject areas
- Pharmacology