Daily rhythm of metyrapone metabolism in rats

Sz Szeberényi, K. Sz Szalay, S. Garattini

Research output: Contribution to journalArticle

Abstract

Plasma levels of metyrapone were measured in rats standardized in an alternating 12-hr-light and 12-hr-dark regimen, every 4 hr over a 24-hr period. The results indicate a circadian periodicity with a half-life at 22.00 hr (10 p.m.) which was approximately 2.5-fold longer than that observed at 10.00 hr (10 a.m.).

Original languageEnglish
Pages (from-to)2767-2769
Number of pages3
JournalBiochemical Pharmacology
Volume18
Issue number12
Publication statusPublished - Dec 1969

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Metyrapone
Periodicity
Metabolism
Half-Life
Rats
Plasmas
Light

ASJC Scopus subject areas

  • Pharmacology

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Szeberényi, S., Szalay, K. S., & Garattini, S. (1969). Daily rhythm of metyrapone metabolism in rats. Biochemical Pharmacology, 18(12), 2767-2769.

Daily rhythm of metyrapone metabolism in rats. / Szeberényi, Sz; Szalay, K. Sz; Garattini, S.

In: Biochemical Pharmacology, Vol. 18, No. 12, 12.1969, p. 2767-2769.

Research output: Contribution to journalArticle

Szeberényi, S, Szalay, KS & Garattini, S 1969, 'Daily rhythm of metyrapone metabolism in rats', Biochemical Pharmacology, vol. 18, no. 12, pp. 2767-2769.
Szeberényi S, Szalay KS, Garattini S. Daily rhythm of metyrapone metabolism in rats. Biochemical Pharmacology. 1969 Dec;18(12):2767-2769.
Szeberényi, Sz ; Szalay, K. Sz ; Garattini, S. / Daily rhythm of metyrapone metabolism in rats. In: Biochemical Pharmacology. 1969 ; Vol. 18, No. 12. pp. 2767-2769.
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