Daily rhythm of metyrapone metabolism in rats

Sz Szeberényi, K. Sz Szalay, S. Garattini

Research output: Contribution to journalArticlepeer-review


Plasma levels of metyrapone were measured in rats standardized in an alternating 12-hr-light and 12-hr-dark regimen, every 4 hr over a 24-hr period. The results indicate a circadian periodicity with a half-life at 22.00 hr (10 p.m.) which was approximately 2.5-fold longer than that observed at 10.00 hr (10 a.m.).

Original languageEnglish
Pages (from-to)2767-2769
Number of pages3
JournalBiochemical Pharmacology
Issue number12
Publication statusPublished - Dec 1969

ASJC Scopus subject areas

  • Pharmacology


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