Abstract
Plasma levels of metyrapone were measured in rats standardized in an alternating 12-hr-light and 12-hr-dark regimen, every 4 hr over a 24-hr period. The results indicate a circadian periodicity with a half-life at 22.00 hr (10 p.m.) which was approximately 2.5-fold longer than that observed at 10.00 hr (10 a.m.).
| Original language | English |
|---|---|
| Pages (from-to) | 2767-2769 |
| Number of pages | 3 |
| Journal | Biochemical Pharmacology |
| Volume | 18 |
| Issue number | 12 |
| Publication status | Published - Dec 1969 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Daily rhythm of metyrapone metabolism in rats. / Szeberényi, Sz; Szalay, K. Sz; Garattini, S.
In: Biochemical Pharmacology, Vol. 18, No. 12, 12.1969, p. 2767-2769.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Daily rhythm of metyrapone metabolism in rats
AU - Szeberényi, Sz
AU - Szalay, K. Sz
AU - Garattini, S.
PY - 1969/12
Y1 - 1969/12
N2 - Plasma levels of metyrapone were measured in rats standardized in an alternating 12-hr-light and 12-hr-dark regimen, every 4 hr over a 24-hr period. The results indicate a circadian periodicity with a half-life at 22.00 hr (10 p.m.) which was approximately 2.5-fold longer than that observed at 10.00 hr (10 a.m.).
AB - Plasma levels of metyrapone were measured in rats standardized in an alternating 12-hr-light and 12-hr-dark regimen, every 4 hr over a 24-hr period. The results indicate a circadian periodicity with a half-life at 22.00 hr (10 p.m.) which was approximately 2.5-fold longer than that observed at 10.00 hr (10 a.m.).
UR - http://www.scopus.com/inward/record.url?scp=49849124980&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49849124980&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:49849124980
VL - 18
SP - 2767
EP - 2769
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
SN - 0006-2952
IS - 12
ER -