Abstract
Objective: Retrospective studies suggest that laparoscopic excision of endometriomas is associated with a reduced responsiveness to ovarian hyperstimulation. In this study, we prospectively evaluated ovarian response to hyperstimulation in women selected for in vitro fertilization and intracytoplasmic sperm injection cycles who previously underwent laparoscopic enucleation of a monolateral endometrioma. Study design: Operated and contralateral intact ovaries of the same patient were compared in terms of number of follicles, number of oocytes retrieved, fertilization rate, and rate of high-quality embryos. Results: Thirty-eight subjects were included. A reduced number of dominant follicles, oocytes, embryos, and high-quality embryos was observed in the operated gonad. The mean percentage of reduction was 60% (95% confidence interval 38-81%), 53% (95% confidence interval 30-75%), 55% (95% confidence interval 28-81%), and 52% (95% confidence interval 17-87%), respectively. Fertilization rate and rate of good-quality embryos were similar. Conclusion: Laparoscopic excision of endometriomas is associated with a quantitative but not a qualitative damage to ovarian reserve.
| Original language | English |
|---|---|
| Pages (from-to) | 1908-1914 |
| Number of pages | 7 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 193 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2005 |
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Keywords
- Endometrioma
- Enucleation
- Laparoscopy
- Ovarian reserve
ASJC Scopus subject areas
- Medicine(all)
- Obstetrics and Gynaecology
Cite this
Damage to ovarian reserve associated with laparoscopic excision of endometriomas : A quantitative rather than a qualitative injury. / Ragni, Guido; Somigliana, Edgardo; Benedetti, Francesca; Paffoni, Alessio; Vegetti, Walter; Restelli, Liliana; Crosignani, Pier Giorgio.
In: American Journal of Obstetrics and Gynecology, Vol. 193, No. 6, 12.2005, p. 1908-1914.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Damage to ovarian reserve associated with laparoscopic excision of endometriomas
T2 - A quantitative rather than a qualitative injury
AU - Ragni, Guido
AU - Somigliana, Edgardo
AU - Benedetti, Francesca
AU - Paffoni, Alessio
AU - Vegetti, Walter
AU - Restelli, Liliana
AU - Crosignani, Pier Giorgio
PY - 2005/12
Y1 - 2005/12
N2 - Objective: Retrospective studies suggest that laparoscopic excision of endometriomas is associated with a reduced responsiveness to ovarian hyperstimulation. In this study, we prospectively evaluated ovarian response to hyperstimulation in women selected for in vitro fertilization and intracytoplasmic sperm injection cycles who previously underwent laparoscopic enucleation of a monolateral endometrioma. Study design: Operated and contralateral intact ovaries of the same patient were compared in terms of number of follicles, number of oocytes retrieved, fertilization rate, and rate of high-quality embryos. Results: Thirty-eight subjects were included. A reduced number of dominant follicles, oocytes, embryos, and high-quality embryos was observed in the operated gonad. The mean percentage of reduction was 60% (95% confidence interval 38-81%), 53% (95% confidence interval 30-75%), 55% (95% confidence interval 28-81%), and 52% (95% confidence interval 17-87%), respectively. Fertilization rate and rate of good-quality embryos were similar. Conclusion: Laparoscopic excision of endometriomas is associated with a quantitative but not a qualitative damage to ovarian reserve.
AB - Objective: Retrospective studies suggest that laparoscopic excision of endometriomas is associated with a reduced responsiveness to ovarian hyperstimulation. In this study, we prospectively evaluated ovarian response to hyperstimulation in women selected for in vitro fertilization and intracytoplasmic sperm injection cycles who previously underwent laparoscopic enucleation of a monolateral endometrioma. Study design: Operated and contralateral intact ovaries of the same patient were compared in terms of number of follicles, number of oocytes retrieved, fertilization rate, and rate of high-quality embryos. Results: Thirty-eight subjects were included. A reduced number of dominant follicles, oocytes, embryos, and high-quality embryos was observed in the operated gonad. The mean percentage of reduction was 60% (95% confidence interval 38-81%), 53% (95% confidence interval 30-75%), 55% (95% confidence interval 28-81%), and 52% (95% confidence interval 17-87%), respectively. Fertilization rate and rate of good-quality embryos were similar. Conclusion: Laparoscopic excision of endometriomas is associated with a quantitative but not a qualitative damage to ovarian reserve.
KW - Endometrioma
KW - Enucleation
KW - Laparoscopy
KW - Ovarian reserve
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UR - http://www.scopus.com/inward/citedby.url?scp=28444439293&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2005.05.056
DO - 10.1016/j.ajog.2005.05.056
M3 - Article
C2 - 16325591
AN - SCOPUS:28444439293
VL - 193
SP - 1908
EP - 1914
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 6
ER -