Damage to ovarian reserve associated with laparoscopic excision of endometriomas: A quantitative rather than a qualitative injury

Guido Ragni, Edgardo Somigliana, Francesca Benedetti, Alessio Paffoni, Walter Vegetti, Liliana Restelli, Pier Giorgio Crosignani

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Objective: Retrospective studies suggest that laparoscopic excision of endometriomas is associated with a reduced responsiveness to ovarian hyperstimulation. In this study, we prospectively evaluated ovarian response to hyperstimulation in women selected for in vitro fertilization and intracytoplasmic sperm injection cycles who previously underwent laparoscopic enucleation of a monolateral endometrioma. Study design: Operated and contralateral intact ovaries of the same patient were compared in terms of number of follicles, number of oocytes retrieved, fertilization rate, and rate of high-quality embryos. Results: Thirty-eight subjects were included. A reduced number of dominant follicles, oocytes, embryos, and high-quality embryos was observed in the operated gonad. The mean percentage of reduction was 60% (95% confidence interval 38-81%), 53% (95% confidence interval 30-75%), 55% (95% confidence interval 28-81%), and 52% (95% confidence interval 17-87%), respectively. Fertilization rate and rate of good-quality embryos were similar. Conclusion: Laparoscopic excision of endometriomas is associated with a quantitative but not a qualitative damage to ovarian reserve.

Original languageEnglish
Pages (from-to)1908-1914
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume193
Issue number6
DOIs
Publication statusPublished - Dec 2005

Fingerprint

Endometriosis
Embryonic Structures
Confidence Intervals
Wounds and Injuries
Fertilization
Oocytes
Intracytoplasmic Sperm Injections
Gonads
Fertilization in Vitro
Ovary
Retrospective Studies
Ovarian Reserve

Keywords

  • Endometrioma
  • Enucleation
  • Laparoscopy
  • Ovarian reserve

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology

Cite this

Damage to ovarian reserve associated with laparoscopic excision of endometriomas : A quantitative rather than a qualitative injury. / Ragni, Guido; Somigliana, Edgardo; Benedetti, Francesca; Paffoni, Alessio; Vegetti, Walter; Restelli, Liliana; Crosignani, Pier Giorgio.

In: American Journal of Obstetrics and Gynecology, Vol. 193, No. 6, 12.2005, p. 1908-1914.

Research output: Contribution to journalArticle

Ragni, Guido ; Somigliana, Edgardo ; Benedetti, Francesca ; Paffoni, Alessio ; Vegetti, Walter ; Restelli, Liliana ; Crosignani, Pier Giorgio. / Damage to ovarian reserve associated with laparoscopic excision of endometriomas : A quantitative rather than a qualitative injury. In: American Journal of Obstetrics and Gynecology. 2005 ; Vol. 193, No. 6. pp. 1908-1914.
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AU - Crosignani, Pier Giorgio

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N2 - Objective: Retrospective studies suggest that laparoscopic excision of endometriomas is associated with a reduced responsiveness to ovarian hyperstimulation. In this study, we prospectively evaluated ovarian response to hyperstimulation in women selected for in vitro fertilization and intracytoplasmic sperm injection cycles who previously underwent laparoscopic enucleation of a monolateral endometrioma. Study design: Operated and contralateral intact ovaries of the same patient were compared in terms of number of follicles, number of oocytes retrieved, fertilization rate, and rate of high-quality embryos. Results: Thirty-eight subjects were included. A reduced number of dominant follicles, oocytes, embryos, and high-quality embryos was observed in the operated gonad. The mean percentage of reduction was 60% (95% confidence interval 38-81%), 53% (95% confidence interval 30-75%), 55% (95% confidence interval 28-81%), and 52% (95% confidence interval 17-87%), respectively. Fertilization rate and rate of good-quality embryos were similar. Conclusion: Laparoscopic excision of endometriomas is associated with a quantitative but not a qualitative damage to ovarian reserve.

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