Abstract
Inflammation is deeply entangled with redox modulation. Triggering of PRRs on inflammatory cells induces ROS generation. As a consequence, activated cells mount antioxidant responses to counteract the possible harmful effects of oxidation. Therefore, when repair is completed, homeostasis is restored. Here, we describe some recent results showing that an exuberant antioxidant response to pro-oxidant inflammatory stimuli modifies not only the intra- but also the extracellular redox and contributes to the outcome of the inflammatory process. In particular, the role of redox modulation in IL-1β secretion, in B lymphocyte differentiation to plasma cells, and in tumor progression will be discussed, and the potential consequences of extracellular redox alterations on DAMP activity will be considered.
| Original language | English |
|---|---|
| Pages (from-to) | 549-555 |
| Number of pages | 7 |
| Journal | Journal of Leukocyte Biology |
| Volume | 86 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 1 2009 |
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Keywords
- B lymphocytes
- Cancer
- Cysteine
- IL-1β
- Oxidative stress
- ROS
ASJC Scopus subject areas
- Cell Biology
- Immunology
Cite this
DAMPs and inflammatory processes : The role of redox in the different outcomes. / Carta, Sonia; Castellani, Patrizia; Delfino, Laura; Tassi, Sara; Venè, Roberta; Rubartelli, Anna.
In: Journal of Leukocyte Biology, Vol. 86, No. 3, 01.09.2009, p. 549-555.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - DAMPs and inflammatory processes
T2 - The role of redox in the different outcomes
AU - Carta, Sonia
AU - Castellani, Patrizia
AU - Delfino, Laura
AU - Tassi, Sara
AU - Venè, Roberta
AU - Rubartelli, Anna
PY - 2009/9/1
Y1 - 2009/9/1
N2 - Inflammation is deeply entangled with redox modulation. Triggering of PRRs on inflammatory cells induces ROS generation. As a consequence, activated cells mount antioxidant responses to counteract the possible harmful effects of oxidation. Therefore, when repair is completed, homeostasis is restored. Here, we describe some recent results showing that an exuberant antioxidant response to pro-oxidant inflammatory stimuli modifies not only the intra- but also the extracellular redox and contributes to the outcome of the inflammatory process. In particular, the role of redox modulation in IL-1β secretion, in B lymphocyte differentiation to plasma cells, and in tumor progression will be discussed, and the potential consequences of extracellular redox alterations on DAMP activity will be considered.
AB - Inflammation is deeply entangled with redox modulation. Triggering of PRRs on inflammatory cells induces ROS generation. As a consequence, activated cells mount antioxidant responses to counteract the possible harmful effects of oxidation. Therefore, when repair is completed, homeostasis is restored. Here, we describe some recent results showing that an exuberant antioxidant response to pro-oxidant inflammatory stimuli modifies not only the intra- but also the extracellular redox and contributes to the outcome of the inflammatory process. In particular, the role of redox modulation in IL-1β secretion, in B lymphocyte differentiation to plasma cells, and in tumor progression will be discussed, and the potential consequences of extracellular redox alterations on DAMP activity will be considered.
KW - B lymphocytes
KW - Cancer
KW - Cysteine
KW - IL-1β
KW - Oxidative stress
KW - ROS
UR - http://www.scopus.com/inward/record.url?scp=70149123249&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70149123249&partnerID=8YFLogxK
U2 - 10.1189/jlb.1008598
DO - 10.1189/jlb.1008598
M3 - Article
C2 - 19564570
AN - SCOPUS:70149123249
VL - 86
SP - 549
EP - 555
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
SN - 0741-5400
IS - 3
ER -