DAMPs and inflammatory processes: The role of redox in the different outcomes

Sonia Carta, Patrizia Castellani, Laura Delfino, Sara Tassi, Roberta Venè, Anna Rubartelli

Research output: Contribution to journalArticle

Abstract

Inflammation is deeply entangled with redox modulation. Triggering of PRRs on inflammatory cells induces ROS generation. As a consequence, activated cells mount antioxidant responses to counteract the possible harmful effects of oxidation. Therefore, when repair is completed, homeostasis is restored. Here, we describe some recent results showing that an exuberant antioxidant response to pro-oxidant inflammatory stimuli modifies not only the intra- but also the extracellular redox and contributes to the outcome of the inflammatory process. In particular, the role of redox modulation in IL-1β secretion, in B lymphocyte differentiation to plasma cells, and in tumor progression will be discussed, and the potential consequences of extracellular redox alterations on DAMP activity will be considered.

Original languageEnglish
Pages (from-to)549-555
Number of pages7
JournalJournal of Leukocyte Biology
Volume86
Issue number3
DOIs
Publication statusPublished - Sep 1 2009

Keywords

  • B lymphocytes
  • Cancer
  • Cysteine
  • IL-1β
  • Oxidative stress
  • ROS

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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