Danazol and stanozolol in long-term prophylactic treatment of hereditary angioedema

Angelo Agostoni, Marco Cicardi, G. Carlo Martignoni, Luigi Bergamaschini, Bianca Marasini

Research output: Contribution to journalArticle

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Abstract

Treatment with 17 α-methyltestosterone and with some synthetic androgens prevents attacks of hereditary angioedema (HAE). However, the potential hepatotoxicity of 17 α-alkylated androgens raises the problem of long-term prophylactic use of these agents. Therefore we compared the efficacy in preventing HAE attacks of 17 α-alkylated steroids (danazol and stanozolol) with non-17 α-alkylated derivatives (quinbolone, nandrolone decanoate and mesterolone). As the latter group proved ineffective, it seems that a drug's efficacy in preventing HAE attacks is connected to its 17 α-alkylation. Moreover, our long-term observations with the minimum effective dose of danazol seem to indicate the absence of important collateral effects.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalJournal of Allergy and Clinical Immunology
Volume65
Issue number1
DOIs
Publication statusPublished - 1980

Fingerprint

Stanozolol
Hereditary Angioedemas
Danazol
Mesterolone
Testosterone Congeners
Methyltestosterone
Alkylation
Androgens
Steroids
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Danazol and stanozolol in long-term prophylactic treatment of hereditary angioedema. / Agostoni, Angelo; Cicardi, Marco; Martignoni, G. Carlo; Bergamaschini, Luigi; Marasini, Bianca.

In: Journal of Allergy and Clinical Immunology, Vol. 65, No. 1, 1980, p. 75-79.

Research output: Contribution to journalArticle

Agostoni, Angelo ; Cicardi, Marco ; Martignoni, G. Carlo ; Bergamaschini, Luigi ; Marasini, Bianca. / Danazol and stanozolol in long-term prophylactic treatment of hereditary angioedema. In: Journal of Allergy and Clinical Immunology. 1980 ; Vol. 65, No. 1. pp. 75-79.
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