Danazol and stanozolol in long-term prophylactic treatment of hereditary angioedema

Angelo Agostoni, Marco Cicardi, G. Carlo Martignoni, Luigi Bergamaschini, Bianca Marasini

Research output: Contribution to journalArticlepeer-review

Abstract

Treatment with 17 α-methyltestosterone and with some synthetic androgens prevents attacks of hereditary angioedema (HAE). However, the potential hepatotoxicity of 17 α-alkylated androgens raises the problem of long-term prophylactic use of these agents. Therefore we compared the efficacy in preventing HAE attacks of 17 α-alkylated steroids (danazol and stanozolol) with non-17 α-alkylated derivatives (quinbolone, nandrolone decanoate and mesterolone). As the latter group proved ineffective, it seems that a drug's efficacy in preventing HAE attacks is connected to its 17 α-alkylation. Moreover, our long-term observations with the minimum effective dose of danazol seem to indicate the absence of important collateral effects.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalJournal of Allergy and Clinical Immunology
Volume65
Issue number1
DOIs
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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