Fourteen patients with idiopathic thrombocytopenic purpura (ITP) refractory to steroids and/or splenectomy were treated with Danazol (200 mg 3 times a day), an androgen with reduced virilizing capacity. After a two-month trial with this drug 5 patients experienced a sustained increase in platelet count. In 3 cases remission lasted more than 12 months and in 2 others it was transient. The drug was well-tolerated in all cases; one patient showed worsening of bleeding due to activation of fibrinolysis.
|Number of pages||3|
|Publication status||Published - 1988|
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