Danazol therapy for idiopathic thrombocytopenic purpura (ITP)

G. Nalli, M. R. Sajeva, G. Carnevale Maffe, E. Ascari

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Fourteen patients with idiopathic thrombocytopenic purpura (ITP) refractory to steroids and/or splenectomy were treated with Danazol (200 mg 3 times a day), an androgen with reduced virilizing capacity. After a two-month trial with this drug 5 patients experienced a sustained increase in platelet count. In 3 cases remission lasted more than 12 months and in 2 others it was transient. The drug was well-tolerated in all cases; one patient showed worsening of bleeding due to activation of fibrinolysis.

Original languageEnglish
Pages (from-to)55-57
Number of pages3
JournalHaematologica
Volume73
Issue number1
Publication statusPublished - 1988

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Danazol
Idiopathic Thrombocytopenic Purpura
Fibrinolysis
Splenectomy
Platelet Count
Pharmaceutical Preparations
Androgens
Therapeutics
Steroids
Hemorrhage

ASJC Scopus subject areas

  • Hematology

Cite this

Nalli, G., Sajeva, M. R., Carnevale Maffe, G., & Ascari, E. (1988). Danazol therapy for idiopathic thrombocytopenic purpura (ITP). Haematologica, 73(1), 55-57.

Danazol therapy for idiopathic thrombocytopenic purpura (ITP). / Nalli, G.; Sajeva, M. R.; Carnevale Maffe, G.; Ascari, E.

In: Haematologica, Vol. 73, No. 1, 1988, p. 55-57.

Research output: Contribution to journalArticle

Nalli, G, Sajeva, MR, Carnevale Maffe, G & Ascari, E 1988, 'Danazol therapy for idiopathic thrombocytopenic purpura (ITP)', Haematologica, vol. 73, no. 1, pp. 55-57.
Nalli, G. ; Sajeva, M. R. ; Carnevale Maffe, G. ; Ascari, E. / Danazol therapy for idiopathic thrombocytopenic purpura (ITP). In: Haematologica. 1988 ; Vol. 73, No. 1. pp. 55-57.
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