Danazol versus a gonadotropin-releasing hormone agonist as preoperative preparation for hysteroscopic metroplasty

L. Fedele, S. Bianchi, L. Gruft, G. Bigatti, M. Busacca

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To compare the efficacy of danazol and a GnRH agonist as preoperative preparation for hysteroscopic metroplasty in women with septate uterus. Design: Prospective randomized clinical study. Setting: Tertiary care center. Patients: Thirty patients with septate uterus. Interventions: The patients were randomized to treatment with danazol 600 mg/d for 2 to 4 weeks (n = 15) or with leuprolide acetate depot 3.75 mg for 2 months (n = 15) as preoperative therapy for hysteroscopic metroplasty. Main Outcome Measures: At the intervention the hysteroscopist evaluated difficulty in dilation of the cervical canal, presence of endometrial fragments, bleeding, difficulty in maneuvering the resectoscope, and operating time. Results: Both the treatments were well tolerated. Metroplasty was simpler overall in the danazol group and also faster in introducing the resectoscope through the cervical canal and maneuvering it in the uterine cavity were both easier. Bleeding was modest in both groups and the anatomic outcome of the operation was similar. Conclusion: Short preoperative preparation with danazol results in favorable operating conditions at limited costs with minimal side effects.

Original languageEnglish
Pages (from-to)186-188
Number of pages3
JournalFertility and Sterility
Volume65
Issue number1
Publication statusPublished - 1996

Keywords

  • danazol
  • GnRH agonist
  • Hysteroscopic metroplasty
  • septate uterus

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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