DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma

Maria Teresa Voso, Daniela Gumiero, Francesco D'Alo', Francesco Guidi, Giovanna Mansueto, Anna Laura Di Febo, Giuseppina Massini, Maurizio Martini, Luigi Maria Larocca, Stefan Hohaus, Giuseppe Leone

Research output: Contribution to journalArticle

Abstract

We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p

Original languageEnglish
Pages (from-to)1252-1256
Number of pages5
JournalHaematologica
Volume91
Issue number9
Publication statusPublished - Sep 2006

Fingerprint

Death-Associated Protein Kinases
Follicular Lymphoma
Bone Marrow
Disease-Free Survival

Keywords

  • DAP-kinase hypermethylation
  • Follicular lymphoma
  • Prognosis

ASJC Scopus subject areas

  • Hematology

Cite this

Voso, M. T., Gumiero, D., D'Alo', F., Guidi, F., Mansueto, G., Di Febo, A. L., ... Leone, G. (2006). DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma. Haematologica, 91(9), 1252-1256.

DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma. / Voso, Maria Teresa; Gumiero, Daniela; D'Alo', Francesco; Guidi, Francesco; Mansueto, Giovanna; Di Febo, Anna Laura; Massini, Giuseppina; Martini, Maurizio; Larocca, Luigi Maria; Hohaus, Stefan; Leone, Giuseppe.

In: Haematologica, Vol. 91, No. 9, 09.2006, p. 1252-1256.

Research output: Contribution to journalArticle

Voso, MT, Gumiero, D, D'Alo', F, Guidi, F, Mansueto, G, Di Febo, AL, Massini, G, Martini, M, Larocca, LM, Hohaus, S & Leone, G 2006, 'DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma', Haematologica, vol. 91, no. 9, pp. 1252-1256.
Voso MT, Gumiero D, D'Alo' F, Guidi F, Mansueto G, Di Febo AL et al. DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma. Haematologica. 2006 Sep;91(9):1252-1256.
Voso, Maria Teresa ; Gumiero, Daniela ; D'Alo', Francesco ; Guidi, Francesco ; Mansueto, Giovanna ; Di Febo, Anna Laura ; Massini, Giuseppina ; Martini, Maurizio ; Larocca, Luigi Maria ; Hohaus, Stefan ; Leone, Giuseppe. / DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma. In: Haematologica. 2006 ; Vol. 91, No. 9. pp. 1252-1256.
@article{ae06bdcb607546d8a353d4a979d6e521,
title = "DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma",
abstract = "We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71{\%}) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67{\%} of samples (48{\%} both positive, 19{\%} both negative). Both mrakers were independent predictors of the disease status (p",
keywords = "DAP-kinase hypermethylation, Follicular lymphoma, Prognosis",
author = "Voso, {Maria Teresa} and Daniela Gumiero and Francesco D'Alo' and Francesco Guidi and Giovanna Mansueto and {Di Febo}, {Anna Laura} and Giuseppina Massini and Maurizio Martini and Larocca, {Luigi Maria} and Stefan Hohaus and Giuseppe Leone",
year = "2006",
month = "9",
language = "English",
volume = "91",
pages = "1252--1256",
journal = "Haematologica",
issn = "0390-6078",
publisher = "NLM (Medline)",
number = "9",

}

TY - JOUR

T1 - DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma

AU - Voso, Maria Teresa

AU - Gumiero, Daniela

AU - D'Alo', Francesco

AU - Guidi, Francesco

AU - Mansueto, Giovanna

AU - Di Febo, Anna Laura

AU - Massini, Giuseppina

AU - Martini, Maurizio

AU - Larocca, Luigi Maria

AU - Hohaus, Stefan

AU - Leone, Giuseppe

PY - 2006/9

Y1 - 2006/9

N2 - We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p

AB - We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p

KW - DAP-kinase hypermethylation

KW - Follicular lymphoma

KW - Prognosis

UR - http://www.scopus.com/inward/record.url?scp=33748761145&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748761145&partnerID=8YFLogxK

M3 - Article

C2 - 16956827

AN - SCOPUS:33748761145

VL - 91

SP - 1252

EP - 1256

JO - Haematologica

JF - Haematologica

SN - 0390-6078

IS - 9

ER -