DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma

Maria Teresa Voso, Daniela Gumiero, Francesco D'Alo', Francesco Guidi, Giovanna Mansueto, Anna Laura Di Febo, Giuseppina Massini, Maurizio Martini, Luigi Maria Larocca, Stefan Hohaus, Giuseppe Leone

Research output: Contribution to journalArticle

Abstract

We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p

Original languageEnglish
Pages (from-to)1252-1256
Number of pages5
JournalHaematologica
Volume91
Issue number9
Publication statusPublished - Sep 2006

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Keywords

  • DAP-kinase hypermethylation
  • Follicular lymphoma
  • Prognosis

ASJC Scopus subject areas

  • Hematology

Cite this

Voso, M. T., Gumiero, D., D'Alo', F., Guidi, F., Mansueto, G., Di Febo, A. L., Massini, G., Martini, M., Larocca, L. M., Hohaus, S., & Leone, G. (2006). DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma. Haematologica, 91(9), 1252-1256.