Abstract
Background-NOX-2, the catalytic subunit of NADPH oxidase, has a key role in the formation of reactive oxidant species and is implicated in impairing flow-mediated dilation (FMD). Dark chocolate exerts artery dilatation via down-regulating NOX2-mediated oxidative stress. The aim of this study was to investigate whether dark chocolate improves walking autonomy in peripheral artery disease (PAD) patients via an oxidative stress-mediated mechanism. Methods and Results-FMD, serum levels of isoprostanes, nitrite/nitrate (NOx) and sNOX2-dp, a marker of blood NOX2 activity, maximal walking distance (MWD) and maximal walking time (MWT) were studied in 20 PAD patients (14 males and 6 females, mean age: 69±9 years) randomly allocated to 40 g of dark chocolate (>85% cocoa) or 40 g of milk chocolate (≤35% cocoa) in a single blind, cross-over design. The above variables were assessed at baseline and 2 hours after chocolate ingestion. Dark chocolate intake significantly increased MWD (+11%; P
| Original language | English |
|---|---|
| Article number | e001072 |
| Journal | Journal of the American Heart Association |
| Volume | 3 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Antioxidant
- Atherosclerosis
- Chocolate
- Oxidant stress
- Peripheral vascular disease
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Dark chocolate acutely improves walking autonomy in patients with peripheral artery disease. / Loffredo, Lorenzo; Perri, Ludovica; Catasca, Elisa; Pignatelli, Pasquale; Brancorsini, Monica; Nocella, Cristina; De Falco, Elena; Bartimoccia, Simona; Frati, Giacomo; Carnevale, Roberto; Violi, Francesco.
In: Journal of the American Heart Association, Vol. 3, No. 4, e001072, 2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dark chocolate acutely improves walking autonomy in patients with peripheral artery disease
AU - Loffredo, Lorenzo
AU - Perri, Ludovica
AU - Catasca, Elisa
AU - Pignatelli, Pasquale
AU - Brancorsini, Monica
AU - Nocella, Cristina
AU - De Falco, Elena
AU - Bartimoccia, Simona
AU - Frati, Giacomo
AU - Carnevale, Roberto
AU - Violi, Francesco
PY - 2014
Y1 - 2014
N2 - Background-NOX-2, the catalytic subunit of NADPH oxidase, has a key role in the formation of reactive oxidant species and is implicated in impairing flow-mediated dilation (FMD). Dark chocolate exerts artery dilatation via down-regulating NOX2-mediated oxidative stress. The aim of this study was to investigate whether dark chocolate improves walking autonomy in peripheral artery disease (PAD) patients via an oxidative stress-mediated mechanism. Methods and Results-FMD, serum levels of isoprostanes, nitrite/nitrate (NOx) and sNOX2-dp, a marker of blood NOX2 activity, maximal walking distance (MWD) and maximal walking time (MWT) were studied in 20 PAD patients (14 males and 6 females, mean age: 69±9 years) randomly allocated to 40 g of dark chocolate (>85% cocoa) or 40 g of milk chocolate (≤35% cocoa) in a single blind, cross-over design. The above variables were assessed at baseline and 2 hours after chocolate ingestion. Dark chocolate intake significantly increased MWD (+11%; P
AB - Background-NOX-2, the catalytic subunit of NADPH oxidase, has a key role in the formation of reactive oxidant species and is implicated in impairing flow-mediated dilation (FMD). Dark chocolate exerts artery dilatation via down-regulating NOX2-mediated oxidative stress. The aim of this study was to investigate whether dark chocolate improves walking autonomy in peripheral artery disease (PAD) patients via an oxidative stress-mediated mechanism. Methods and Results-FMD, serum levels of isoprostanes, nitrite/nitrate (NOx) and sNOX2-dp, a marker of blood NOX2 activity, maximal walking distance (MWD) and maximal walking time (MWT) were studied in 20 PAD patients (14 males and 6 females, mean age: 69±9 years) randomly allocated to 40 g of dark chocolate (>85% cocoa) or 40 g of milk chocolate (≤35% cocoa) in a single blind, cross-over design. The above variables were assessed at baseline and 2 hours after chocolate ingestion. Dark chocolate intake significantly increased MWD (+11%; P
KW - Antioxidant
KW - Atherosclerosis
KW - Chocolate
KW - Oxidant stress
KW - Peripheral vascular disease
UR - http://www.scopus.com/inward/record.url?scp=84920741927&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920741927&partnerID=8YFLogxK
U2 - 10.1161/JAHA.114.001072
DO - 10.1161/JAHA.114.001072
M3 - Article
C2 - 24990275
AN - SCOPUS:84920741927
VL - 3
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
SN - 2047-9980
IS - 4
M1 - e001072
ER -