Dasatinib is safe and effective in unselected chronic myeloid leukaemia elderly patients resistant/intolerant to imatinib

Roberto Latagliata; Massimo Breccia; Fausto Castagnetti; Fabio Stagno; Luigiana Luciano; Antonella Gozzini; Stefano Ulisciani; Francesco Cavazzini; Mario Annunziata; Federica Sorà; Antonella Russo Rossi; Patrizia Pregno; Enrico Montefusco; Elisabetta Abruzzese; Elena Crisà; Pellegrino Musto; Mario Tiribelli; Gianni Binotto; Ubaldo Occhini; Costanzo Feo; Paolo Vigneri; Valeria Santini; Carmen Fava; Giannantonio Rosti; Giuliana Alimena

doi:10.1016/j.leukres.2011.05.015

Dasatinib is safe and effective in unselected chronic myeloid leukaemia elderly patients resistant/intolerant to imatinib

Roberto Latagliata, Massimo Breccia, Fausto Castagnetti, Fabio Stagno, Luigiana Luciano, Antonella Gozzini, Stefano Ulisciani, Francesco Cavazzini, Mario Annunziata, Federica Sorà, Antonella Russo Rossi, Patrizia Pregno, Enrico Montefusco, Elisabetta Abruzzese, Elena Crisà, Pellegrino Musto, Mario Tiribelli, Gianni Binotto, Ubaldo Occhini, Costanzo FeoPaolo Vigneri, Valeria Santini, Carmen Fava, Giannantonio Rosti, Giuliana Alimena

IRCCS Centro di Riferimento Oncologico della Basilicata (CROB)

Research output: Contribution to journal › Article › peer-review

Abstract

To highlight dasatinib role in the elderly, 125 unselected patients with CP-CML aged >60 years resistant/intolerant to imatinib were retrospectively evaluated. Grade 3-4 haematological and extra-haematological toxicities were reported in 39 (31.2%) and 34 (27.2%) patients; grade 3-4 haematological toxicity was higher in patients with 140. mg starting dose (50.0% vs 19.6%, p = 0.001). Grade 3-4 pleuro-pericardial effusions occurred in 10 patients (8.0%). Dose reductions were more common in patients with 140. mg (88.4% vs 26.7%, p<0.001). Of 122 evaluable patients, 72 (59.1%) had cytogenetic response [12 (9.8%) partial, 60 (49.3%) complete]. Overall, 38/60 patients in complete CyR also achieved a molecular response. Cumulative OS at 24 and 48 months were 93.1% (95% CI 88.4-97.8) and 84.2% (95% CI 74.6-93.7). Dasatinib, at the recommended dose of 100. mg/day, is effective and safe also in unselected elderly subjects.

Original language	English
Pages (from-to)	1164-1169
Number of pages	6
Journal	Leukemia Research
Volume	35
Issue number	9
DOIs	https://doi.org/10.1016/j.leukres.2011.05.015
Publication status	Published - Sep 2011

Keywords

Chronic Myeloid Leukaemia
Dasatinib
Elderly
Safety

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology

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10.1016/j.leukres.2011.05.015

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Latagliata, R., Breccia, M., Castagnetti, F., Stagno, F., Luciano, L., Gozzini, A., Ulisciani, S., Cavazzini, F., Annunziata, M., Sorà, F., Rossi, A. R., Pregno, P., Montefusco, E., Abruzzese, E., Crisà, E., Musto, P., Tiribelli, M., Binotto, G., Occhini, U., ... Alimena, G. (2011). Dasatinib is safe and effective in unselected chronic myeloid leukaemia elderly patients resistant/intolerant to imatinib. Leukemia Research, 35(9), 1164-1169. https://doi.org/10.1016/j.leukres.2011.05.015

Dasatinib is safe and effective in unselected chronic myeloid leukaemia elderly patients resistant/intolerant to imatinib. / Latagliata, Roberto; Breccia, Massimo; Castagnetti, Fausto; Stagno, Fabio; Luciano, Luigiana; Gozzini, Antonella; Ulisciani, Stefano; Cavazzini, Francesco; Annunziata, Mario; Sorà, Federica; Rossi, Antonella Russo; Pregno, Patrizia; Montefusco, Enrico; Abruzzese, Elisabetta; Crisà, Elena; Musto, Pellegrino; Tiribelli, Mario; Binotto, Gianni; Occhini, Ubaldo; Feo, Costanzo; Vigneri, Paolo; Santini, Valeria; Fava, Carmen; Rosti, Giannantonio; Alimena, Giuliana.

In: Leukemia Research, Vol. 35, No. 9, 09.2011, p. 1164-1169.

Research output: Contribution to journal › Article › peer-review

Latagliata, R, Breccia, M, Castagnetti, F, Stagno, F, Luciano, L, Gozzini, A, Ulisciani, S, Cavazzini, F, Annunziata, M, Sorà, F, Rossi, AR, Pregno, P, Montefusco, E, Abruzzese, E, Crisà, E, Musto, P, Tiribelli, M, Binotto, G, Occhini, U, Feo, C, Vigneri, P, Santini, V, Fava, C, Rosti, G & Alimena, G 2011, 'Dasatinib is safe and effective in unselected chronic myeloid leukaemia elderly patients resistant/intolerant to imatinib', Leukemia Research, vol. 35, no. 9, pp. 1164-1169. https://doi.org/10.1016/j.leukres.2011.05.015

Latagliata, Roberto ; Breccia, Massimo ; Castagnetti, Fausto ; Stagno, Fabio ; Luciano, Luigiana ; Gozzini, Antonella ; Ulisciani, Stefano ; Cavazzini, Francesco ; Annunziata, Mario ; Sorà, Federica ; Rossi, Antonella Russo ; Pregno, Patrizia ; Montefusco, Enrico ; Abruzzese, Elisabetta ; Crisà, Elena ; Musto, Pellegrino ; Tiribelli, Mario ; Binotto, Gianni ; Occhini, Ubaldo ; Feo, Costanzo ; Vigneri, Paolo ; Santini, Valeria ; Fava, Carmen ; Rosti, Giannantonio ; Alimena, Giuliana. / Dasatinib is safe and effective in unselected chronic myeloid leukaemia elderly patients resistant/intolerant to imatinib. In: Leukemia Research. 2011 ; Vol. 35, No. 9. pp. 1164-1169.

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abstract = "To highlight dasatinib role in the elderly, 125 unselected patients with CP-CML aged >60 years resistant/intolerant to imatinib were retrospectively evaluated. Grade 3-4 haematological and extra-haematological toxicities were reported in 39 (31.2%) and 34 (27.2%) patients; grade 3-4 haematological toxicity was higher in patients with 140. mg starting dose (50.0% vs 19.6%, p = 0.001). Grade 3-4 pleuro-pericardial effusions occurred in 10 patients (8.0%). Dose reductions were more common in patients with 140. mg (88.4% vs 26.7%, p<0.001). Of 122 evaluable patients, 72 (59.1%) had cytogenetic response [12 (9.8%) partial, 60 (49.3%) complete]. Overall, 38/60 patients in complete CyR also achieved a molecular response. Cumulative OS at 24 and 48 months were 93.1% (95% CI 88.4-97.8) and 84.2% (95% CI 74.6-93.7). Dasatinib, at the recommended dose of 100. mg/day, is effective and safe also in unselected elderly subjects.",

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AU - Ulisciani, Stefano

AU - Cavazzini, Francesco

AU - Annunziata, Mario

AU - Sorà, Federica

AU - Rossi, Antonella Russo

AU - Pregno, Patrizia

AU - Montefusco, Enrico

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Dasatinib is safe and effective in unselected chronic myeloid leukaemia elderly patients resistant/intolerant to imatinib

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Keywords

ASJC Scopus subject areas

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