Daytime autonomic activity in idiopathic rapid eye movement sleep behavior disorder: a preliminary study

Camilla Rocchi, Fabio Placidi, Claudio Liguori, Chiara Del Bianco, Benedetta Lauretti, Marina Diomedi, Antonio Pisani, Nicola B. Mercuri, Francesca Izzi

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Abstract

© 2018 Elsevier B.V. Ojective: To investigate cardiovascular and sudomotor autonomic functions in patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) during wakefulness compared to patients with Parkinson's disease (PD) and healthy subjects. Methods: Drug-naïve iRBD patients, PD patients and healthy controls underwent cardiovascular function tests including head-up tilt test (HUTT), Valsalva maneuver, deep breathing, hand grip, and cold face. Heart rate variability (HRV) analysis was performed in the frequency domain using an autoregressive algorithm in the rest supine condition and during HUTT. Sudomotor function was assessed through Sudoscan. Results: Fourteen iRBD patients, 17 PD patients and 12 healthy controls were included in the study. In the supine resting condition, the baseline values of systolic and diastolic blood pressure and heart rate were comparable in all groups. At Valsalva maneuver, iRBD patients and PD patients showed an overshoot which was significantly lower than controls. In addition, iRBD patients showed a significant reduction of sinus arrhythmia at deep breathing compared to controls. Cardiovascular responses to cold face were similar in the three groups while isometric handgrip was significantly reduced in PD patients with respect to healthy subjects. Spectral analysis of HRV showed no significant differences among iRBD, PD patients and controls in the supine resting condition; whereas during HUTT the low-frequency (LF) component of HRV was significantly higher in controls with respect to iRBD and the high-frequency (HF) component was significantly higher in iRBD patients compared to controls. In addition, a significant increase in the LF/HF ratio in healthy subjects was detected compared to iRBD. Finally, four out of 14 iRBD patients (29%) and nine of 17 PD patients (53%) had a sudomotor dysfunction. Conclusions: Our findings obtained in de novo iRBD and PD patients indicate that some alterations of the autonomic nervous system are shared by both groups of patients, reinforcing the close link between the two pathologies, and show an autonomic fragility during wakefulness in iRBD that mainly arises under stress conditions.
Original languageEnglish
Pages (from-to)163-167
Number of pages5
JournalSleep Medicine
Volume52
DOIs
Publication statusPublished - Dec 1 2018

Fingerprint

REM Sleep Behavior Disorder
Parkinson Disease
Heart Rate
Valsalva Maneuver
Healthy Volunteers
Wakefulness
Head
Respiration
Sinus Arrhythmia
Blood Pressure

Keywords

  • Autonomic nervous system
  • Cardiovascular reflexes
  • Heart rate variability
  • Parkinson's disease
  • REM sleep behavior disorder
  • Sudomotor function

Cite this

Rocchi, C., Placidi, F., Liguori, C., Del Bianco, C., Lauretti, B., Diomedi, M., ... Izzi, F. (2018). Daytime autonomic activity in idiopathic rapid eye movement sleep behavior disorder: a preliminary study. Sleep Medicine, 52, 163-167. https://doi.org/10.1016/j.sleep.2018.08.023

Daytime autonomic activity in idiopathic rapid eye movement sleep behavior disorder: a preliminary study. / Rocchi, Camilla; Placidi, Fabio; Liguori, Claudio; Del Bianco, Chiara; Lauretti, Benedetta; Diomedi, Marina; Pisani, Antonio; Mercuri, Nicola B.; Izzi, Francesca.

In: Sleep Medicine, Vol. 52, 01.12.2018, p. 163-167.

Research output: Contribution to journalArticle

Rocchi, Camilla ; Placidi, Fabio ; Liguori, Claudio ; Del Bianco, Chiara ; Lauretti, Benedetta ; Diomedi, Marina ; Pisani, Antonio ; Mercuri, Nicola B. ; Izzi, Francesca. / Daytime autonomic activity in idiopathic rapid eye movement sleep behavior disorder: a preliminary study. In: Sleep Medicine. 2018 ; Vol. 52. pp. 163-167.
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