DC-ATLAS: A systems biology resource to dissect receptor specific signal transduction in dendritic cells

Duccio Cavalieri, Damariz Rivero, Luca Beltrame, Sonja I. Buschow, Enrica Calura, Lisa Rizzetto, Sandra Gessani, Maria C. Gauzzi, Walter Reith, Andreas Baur, Roberto Bonaiuti, Marco Brandizi, Carlotta De Filippo, Ugo D'Oro, Sorin Draghici, Isabelle Dunand-Sauthier, Evelina Gatti, Francesca Granucci, Michaela Gündel, Matthijs KramerMirela Kuka, Arpad Lanyi, Cornelis J M Melief, Nadine Van Montfoort, Renato Ostuni, Philippe Pierre, Razvan Popovici, Eva Rajnavolgyi, Stephan Schierer, Gerold Schuler, Vassili Soumelis, Andrea Splendiani, Irene Stefanini, Maria G. Torcia, Ivan Zanoni, Raphael Zollinger, Carl G. Figdor, Jonathan M. Austyn

Research output: Contribution to journalArticlepeer-review


Background: The advent of Systems Biology has been accompanied by the blooming of pathway databases. Currently pathways are defined generically with respect to the organ or cell type where a reaction takes place. The cell type specificity of the reactions is the foundation of immunological research, and capturing this specificity is of paramount importance when using pathway-based analyses to decipher complex immunological datasets. Here, we present DC-ATLAS, a novel and versatile resource for the interpretation of high-throughput data generated perturbing the signaling network of dendritic cells (DCs). Results: Pathways are annotated using a novel data model, the Biological Connection Markup Language (BCML), a SBGN-compliant data format developed to store the large amount of information collected. The application of DC-ATLAS to pathway-based analysis of the transcriptional program of DCs stimulated with agonists of the toll-like receptor family allows an integrated description of the flow of information from the cellular sensors to the functional outcome, capturing the temporal series of activation events by grouping sets of reactions that occur at different time points in well-defined functional modules. Conclusions: The initiative significantly improves our understanding of DC biology and regulatory networks. Developing a systems biology approach for immune system holds the promise of translating knowledge on the immune system into more successful immunotherapy strategies.

Original languageEnglish
Article number10
JournalImmunome Research
Issue number1
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology
  • Computational Theory and Mathematics
  • Applied Mathematics
  • Computer Science Applications


Dive into the research topics of 'DC-ATLAS: A systems biology resource to dissect receptor specific signal transduction in dendritic cells'. Together they form a unique fingerprint.

Cite this