DC-SIGN polymorphisms are associated to type 1 diabetes mellitus

Ronaldo Celerino da Silva, Nathália de Alencar Cunha Tavares, Ronald Moura, AntÔnio Coelho, Rafael Lima Guimarães, Jacqueline Araújo, Sergio Crovella, Lucas André Cavalcanti Brandão, Jaqueline de Azevêdo Silva

Research output: Contribution to journalArticle

Abstract

Type I diabetes mellitus (T1DM) is an autoimmune disorder featured by raised glucoses levels. It has been hypothesised that raised glucose levels in T1DM might be recognised as PAMPs, leading to immune response by overloading the cell receptors for pathogens recognition. DC-SIGN is a transmembrane protein, present in dendritic cells (DC) and macrophages: it has an important role in inflammatory response and T cells activation. Notably, DC-SIGN activation and triggering of the immune response depend on the type of ligand, which may lead to a pro or anti-inflammatory pathway. In our association study, we analysed the SNPs rs4804803 (-336 A>G) and rs735239 (-871 A>G), both at DC-SIGN promoter region, in 210 T1DM patients and 157 healthy controls, also looking for a correlation with the age of onset of the disease. We found that the allele G and genotypes G/G and A/G of SNP-871 (rs735239), as well as the alleles G-G (rs735239-rs4804803) and genotypes combined AA-GG (rs735239-rs4804803) were associated with protection of T1DM development. We did not find association between these variations with the age of onset of the disease and the presence of other autoimmune disorders. Our results suggest that SNPs in DC-SIGN promoter region can be associated to protection for T1DM in the Northeast Brazilian population.

Original languageEnglish
Pages (from-to)859-865
Number of pages7
JournalImmunobiology
Volume219
Issue number11
DOIs
Publication statusPublished - Nov 1 2014

Keywords

  • DC-SIGN
  • SNPs
  • T1DM

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology
  • Medicine(all)

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  • Cite this

    da Silva, R. C., de Alencar Cunha Tavares, N., Moura, R., Coelho, A., Guimarães, R. L., Araújo, J., Crovella, S., Brandão, L. A. C., & de Azevêdo Silva, J. (2014). DC-SIGN polymorphisms are associated to type 1 diabetes mellitus. Immunobiology, 219(11), 859-865. https://doi.org/10.1016/j.imbio.2014.07.011