DCEP chemotherapy followed by a single, fixed dose of pegylated filgrastim allows adequate stem cell mobilization in multiple myeloma patients

Patrizia Zappasodi, Anna Maria Nosari, Cesare Astori, Dennis Ciapanna, Maurizio Bonfichi, Marzia Varettoni, Silvia Mangiacavalli, Enrica Morra, Mario Lazzarino, Alessandro Corso

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Abstract

BACKGROUND: Pegylated filgrastim (PEG-f), a long-lasting granulocyte-colony-stimulating factor, has been used in different hematologic conditions to shorten chemotherapy-induced neutropenia and to mobilize peripheral blood stem cells. Data on mobilization efficacy in patients with multiple myeloma are, however, still limited. STUDY DESIGN AND METHODS: The feasibility and mobilizing capacity of DCEP chemotherapy followed by a single subcutaneous dose of 6 mg of PEG-f in 23 myeloma patients (11 females and 12 males) whose median age was 55 years (range, 31-67 years) were investigated. RESULTS: The median number of CD34+ cells collected was 5.72 × 10 6 per kg body weight with a range between 0 × 106 and 29.4 × 106 per kg body weight. Twenty patients (87%) yielded more than 2 × 106 per kg body weight CD34+ cells. Among the 22 patients who mobilized some CD34+ cells, 27 leukapheresis procedures were carried out (a single leukapheresis procedure in 17 patients and 2 leukapheresis procedures in 5). The median interval between the start of chemotherapy and the first leukapheresis procedure was 12 days (range, 11-16 days). With regard to tolerability, 7 patients complained of mild to moderate back pain, controlled with oral analgesics. No patient was hospitalized, and no fever or infections occurred. CONCLUSION: These results, compared with those previously reported for the DCEP-filgrastim combination, suggest that DCEP chemotherapy followed by PEG-f is a promising combination to mobilize peripheral blood stem cells in myeloma patients.

Original languageEnglish
Pages (from-to)857-860
Number of pages4
JournalTransfusion
Volume48
Issue number5
DOIs
Publication statusPublished - May 2008

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ASJC Scopus subject areas

  • Immunology
  • Hematology

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