DCEP (dexamethasone, cyclophosphamide, etoposide, and cisplatin) is an effective regimen for peripheral blood stem cell collection in multiple myeloma

M. Lazzarino, A. Corso, L. Barbarano, E. P. Alessandrino, R. Cairoli, G. Pinotti, G. Ucci, L. Uziel, F. Rodeghiero, S. Fava, D. Ferrari, M. Fiumanò, G. Frigerio, L. Isa, A. Luraschi, S. Montanara, S. Morandi, D. Perego, A. Santagostino, M. SavarèA. Vismara, E. Morra

Research output: Contribution to journalArticle

Abstract

DCEP (dexamethasone, cyclophosphamide, etoposide, and cisplatin) has proved to be an effective salvage therapy for refractory-relapsed MM patients. Little is known, however, about its potential as mobilizing therapy. The aim of this study was to evaluate the efficacy of DCEP in mobilizing PBSC and to define its toxicity. Fifty-five MM patients received DCEP followed by GCSF as part of high-dose programs including autologous transplantation. At the time of mobilization, 40 patients had previously received VAD only, and 15 alkylating agents. Mobilization was successful (minimum number of CD34+ cells 2 × 106/kg) in 48/55 patients (87%), and 41/55 patients (75%) collected >4 × 106/kg CD34+ cells. Of the seven patients who did not mobilize stem cells, five (71%) had been previously exposed to alkylating agents. The median number of CD34+ cells harvested was 5.8 × 106/kg (range 2.1-22.4). There was no treatment-related mortality. The side-effects of DCEP were always tolerable. No neutropenia

Original languageEnglish
Pages (from-to)835-839
Number of pages5
JournalBone Marrow Transplantation
Volume28
Issue number9
DOIs
Publication statusPublished - 2001

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Keywords

  • Chemotheraphy
  • Mobilization
  • Myeloma
  • Peripheral stem cell
  • Purging in vivo

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Lazzarino, M., Corso, A., Barbarano, L., Alessandrino, E. P., Cairoli, R., Pinotti, G., Ucci, G., Uziel, L., Rodeghiero, F., Fava, S., Ferrari, D., Fiumanò, M., Frigerio, G., Isa, L., Luraschi, A., Montanara, S., Morandi, S., Perego, D., Santagostino, A., ... Morra, E. (2001). DCEP (dexamethasone, cyclophosphamide, etoposide, and cisplatin) is an effective regimen for peripheral blood stem cell collection in multiple myeloma. Bone Marrow Transplantation, 28(9), 835-839. https://doi.org/10.1038/sj.bmt.1703240