De novo cancers in paediatric renal transplant recipients: A multicentre analysis within the North Italy Transplant programme (NITp), Italy

A. Nocera, L. Ghio, R. Dall'Amico, I. Fontana, M. Cardillo, L. Berardinelli, G. F. Zanon, M. Scalamogna, G. Zacchello, U. Valente, F. Ginevri

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The purpose of this study was to determine the frequency and the outcome of de novo malignancies in a cohort of renal transplant paediatric patients. The records of 493 kidney transplants, carried out in 454 paediatric recipients at the three paediatric transplant centres of the North Italy Transplant programme (NITp, Italy) were reviewed. 10 cases of malignancies (2.2%) comprising both PTLD (post-transplant lymphoproliferative disorders) (6 cases, 1.3%) and non-PTLD malignancies (4 cases, 0.88%) were reported. Non-PTLD included one urothelial carcinoma and one Wilms' tumour of the recipient's left native kidney, one abdominal dysgerminoma and one optic nerve glioma of the left eye. The PTLD consisted of localised or disseminated Epstein-Barr virus (EBV)-associated B-lymphocyte monoclonal (5 cases) and polyclonal (1 case) proliferations. All patients suffering from PTLD had been EBV-negative at the time of transplantion, but developed EBV primary infection after transplantion. All PTLD patient donors were EBV-positive. In addition, all but 1 patient received, before and/or after transplantation, a range of immunosuppressive drugs in addition to the baseline prophylactic immunosuppressive regimen. Moreover, 3 patients suffered from syndromes associated with a genetic predisposition to cancer. Finally, the malignancies reported here were associated with 20% graft failure and 20% mortality rates. Copyright (C) 2000.

Original languageEnglish
Pages (from-to)80-86
Number of pages7
JournalEuropean Journal of Cancer
Volume36
Issue number1
DOIs
Publication statusPublished - Jan 2000

Fingerprint

Italy
Pediatrics
Transplants
Kidney
Lymphoproliferative Disorders
Neoplasms
Human Herpesvirus 4
Immunosuppressive Agents
Transplant Recipients
Optic Nerve Glioma
Dysgerminoma
Epstein-Barr Virus Infections
Wilms Tumor
Genetic Predisposition to Disease
B-Lymphocytes
Transplantation
Tissue Donors
Carcinoma
Mortality

Keywords

  • Denys-Drash syndrome
  • Epstein-Barr virus
  • Frasier syndrome
  • Immunosuppressive therapy
  • Paediatric graft recipients
  • Post-transplant lymphoproliferative disorders
  • Post-transplant tumours
  • Renal transplantation

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

De novo cancers in paediatric renal transplant recipients : A multicentre analysis within the North Italy Transplant programme (NITp), Italy. / Nocera, A.; Ghio, L.; Dall'Amico, R.; Fontana, I.; Cardillo, M.; Berardinelli, L.; Zanon, G. F.; Scalamogna, M.; Zacchello, G.; Valente, U.; Ginevri, F.

In: European Journal of Cancer, Vol. 36, No. 1, 01.2000, p. 80-86.

Research output: Contribution to journalArticle

Nocera, A, Ghio, L, Dall'Amico, R, Fontana, I, Cardillo, M, Berardinelli, L, Zanon, GF, Scalamogna, M, Zacchello, G, Valente, U & Ginevri, F 2000, 'De novo cancers in paediatric renal transplant recipients: A multicentre analysis within the North Italy Transplant programme (NITp), Italy', European Journal of Cancer, vol. 36, no. 1, pp. 80-86. https://doi.org/10.1016/S0959-8049(99)00234-8
Nocera, A. ; Ghio, L. ; Dall'Amico, R. ; Fontana, I. ; Cardillo, M. ; Berardinelli, L. ; Zanon, G. F. ; Scalamogna, M. ; Zacchello, G. ; Valente, U. ; Ginevri, F. / De novo cancers in paediatric renal transplant recipients : A multicentre analysis within the North Italy Transplant programme (NITp), Italy. In: European Journal of Cancer. 2000 ; Vol. 36, No. 1. pp. 80-86.
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abstract = "The purpose of this study was to determine the frequency and the outcome of de novo malignancies in a cohort of renal transplant paediatric patients. The records of 493 kidney transplants, carried out in 454 paediatric recipients at the three paediatric transplant centres of the North Italy Transplant programme (NITp, Italy) were reviewed. 10 cases of malignancies (2.2{\%}) comprising both PTLD (post-transplant lymphoproliferative disorders) (6 cases, 1.3{\%}) and non-PTLD malignancies (4 cases, 0.88{\%}) were reported. Non-PTLD included one urothelial carcinoma and one Wilms' tumour of the recipient's left native kidney, one abdominal dysgerminoma and one optic nerve glioma of the left eye. The PTLD consisted of localised or disseminated Epstein-Barr virus (EBV)-associated B-lymphocyte monoclonal (5 cases) and polyclonal (1 case) proliferations. All patients suffering from PTLD had been EBV-negative at the time of transplantion, but developed EBV primary infection after transplantion. All PTLD patient donors were EBV-positive. In addition, all but 1 patient received, before and/or after transplantation, a range of immunosuppressive drugs in addition to the baseline prophylactic immunosuppressive regimen. Moreover, 3 patients suffered from syndromes associated with a genetic predisposition to cancer. Finally, the malignancies reported here were associated with 20{\%} graft failure and 20{\%} mortality rates. Copyright (C) 2000.",
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AU - Ghio, L.

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AU - Fontana, I.

AU - Cardillo, M.

AU - Berardinelli, L.

AU - Zanon, G. F.

AU - Scalamogna, M.

AU - Zacchello, G.

AU - Valente, U.

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N2 - The purpose of this study was to determine the frequency and the outcome of de novo malignancies in a cohort of renal transplant paediatric patients. The records of 493 kidney transplants, carried out in 454 paediatric recipients at the three paediatric transplant centres of the North Italy Transplant programme (NITp, Italy) were reviewed. 10 cases of malignancies (2.2%) comprising both PTLD (post-transplant lymphoproliferative disorders) (6 cases, 1.3%) and non-PTLD malignancies (4 cases, 0.88%) were reported. Non-PTLD included one urothelial carcinoma and one Wilms' tumour of the recipient's left native kidney, one abdominal dysgerminoma and one optic nerve glioma of the left eye. The PTLD consisted of localised or disseminated Epstein-Barr virus (EBV)-associated B-lymphocyte monoclonal (5 cases) and polyclonal (1 case) proliferations. All patients suffering from PTLD had been EBV-negative at the time of transplantion, but developed EBV primary infection after transplantion. All PTLD patient donors were EBV-positive. In addition, all but 1 patient received, before and/or after transplantation, a range of immunosuppressive drugs in addition to the baseline prophylactic immunosuppressive regimen. Moreover, 3 patients suffered from syndromes associated with a genetic predisposition to cancer. Finally, the malignancies reported here were associated with 20% graft failure and 20% mortality rates. Copyright (C) 2000.

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