De novo focal glomerular sclerosis in an identical twin renal transplant recipient

Emilio Rivolta, Claudio Ponticelli, Enrico Imbasciati, Antonio Vegeto

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A patient with end-stage renal failure caused by bilateral kidney stones received a kidney transplant from his identical twin. No immunosuppressive therapy was given. After a few days he developed a urinary fistula from a polar artery section, which spontaneously healed. Renal function remained subnormal, blood pressure and urinalysis were normal. After one year proteinuria appeared, and after about four years it entered a nephrotic range. Renal biopsy showed focal glomerular sclerosis (FGS). In the following years progressive renal insufficiency and arterial hypertension developed, and the patient had to be submitted to regular dialysis about 9 years after transplantation. As far as we know this is the first case of late renal failure in an isograft related to the development of de novo FGS. It is suggested that de novo FGS in this isotransplant was related to the partial loss of renal mass caused by polar necrosis, which caused glomerular hyperfiltration. Another possible contributing factor may be kidney denervation, which removes an important mechanism for adjustment of renal arterial flow.

Original languageEnglish
Pages (from-to)328-331
Number of pages4
JournalTransplantation
Volume35
Issue number4
Publication statusPublished - 1983

Fingerprint

Monozygotic Twins
Sclerosis
Kidney
Isografts
Renal Insufficiency
Urinary Fistula
Urinalysis
Kidney Calculi
Denervation
Immunosuppressive Agents
Proteinuria
Chronic Kidney Failure
Transplant Recipients
Dialysis
Necrosis
Arteries
Transplantation
Blood Pressure
Hypertension
Transplants

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Rivolta, E., Ponticelli, C., Imbasciati, E., & Vegeto, A. (1983). De novo focal glomerular sclerosis in an identical twin renal transplant recipient. Transplantation, 35(4), 328-331.

De novo focal glomerular sclerosis in an identical twin renal transplant recipient. / Rivolta, Emilio; Ponticelli, Claudio; Imbasciati, Enrico; Vegeto, Antonio.

In: Transplantation, Vol. 35, No. 4, 1983, p. 328-331.

Research output: Contribution to journalArticle

Rivolta, E, Ponticelli, C, Imbasciati, E & Vegeto, A 1983, 'De novo focal glomerular sclerosis in an identical twin renal transplant recipient', Transplantation, vol. 35, no. 4, pp. 328-331.
Rivolta E, Ponticelli C, Imbasciati E, Vegeto A. De novo focal glomerular sclerosis in an identical twin renal transplant recipient. Transplantation. 1983;35(4):328-331.
Rivolta, Emilio ; Ponticelli, Claudio ; Imbasciati, Enrico ; Vegeto, Antonio. / De novo focal glomerular sclerosis in an identical twin renal transplant recipient. In: Transplantation. 1983 ; Vol. 35, No. 4. pp. 328-331.
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