De novo malignancies after liver transplantation: The effect of immunosuppression-personal data and review of literature

Tommaso Maria Manzia, Roberta Angelico, Carlo Gazia, Ilaria Lenci, Martina Milana, Oludamilola T. Ademoyero, Domiziana Pedini, Luca Toti, Marco Spada, Giuseppe Tisone, Leonardo Baiocchi

Research output: Contribution to journalReview article

Abstract

BACKGROUND Immunosuppression has undoubtedly raised the overall positive outcomes in the post-operative management of solid organ transplantation. However, long-term exposure to immunosuppression is associated with critical systemic morbidities. De novo malignancies following orthotopic liver transplants (OLTs) are a serious threat in pediatric and adult transplant individuals. Data from different experiences were reported and compared to assess the connection between immunosuppression and de novo malignancies in liver transplant patients. AIM To study the role of immunosuppression on the incidence of de novo malignancies in liver transplant recipients. METHODS A systematic literature examination about de novo malignancies and immunosuppression weaning in adult and pediatric OLT recipients was described in the present review. Worldwide data were collected from highly qualified institutions performing OLTs. Patient follow-up, immunosuppression discontinuation and incidence of de novo malignancies were reported. Likewise, the review assesses the differences in adult and pediatric recipients by describing the adopted immunosuppression regimens and the different type of diagnosed solid and blood malignancy.

Original languageEnglish
Pages (from-to)5356-5375
Number of pages20
JournalWorld Journal of Gastroenterology
Volume25
Issue number35
DOIs
Publication statusPublished - Sep 21 2019

Keywords

  • Adult liver transplant
  • Cancer
  • Clinical operationaltolerance
  • De novo malignancies
  • Graft rejection
  • Immune system
  • Immunosuppression minimization
  • Immunosuppression weaning
  • Pediatric liver transplant

ASJC Scopus subject areas

  • Gastroenterology

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  • Cite this

    Manzia, T. M., Angelico, R., Gazia, C., Lenci, I., Milana, M., Ademoyero, O. T., Pedini, D., Toti, L., Spada, M., Tisone, G., & Baiocchi, L. (2019). De novo malignancies after liver transplantation: The effect of immunosuppression-personal data and review of literature. World Journal of Gastroenterology, 25(35), 5356-5375. https://doi.org/10.3748/wjg.v25.i35.5356