TY - JOUR
T1 - De novo malignancies after liver transplantation
T2 - The effect of immunosuppression-personal data and review of literature
AU - Manzia, Tommaso Maria
AU - Angelico, Roberta
AU - Gazia, Carlo
AU - Lenci, Ilaria
AU - Milana, Martina
AU - Ademoyero, Oludamilola T.
AU - Pedini, Domiziana
AU - Toti, Luca
AU - Spada, Marco
AU - Tisone, Giuseppe
AU - Baiocchi, Leonardo
PY - 2019/9/21
Y1 - 2019/9/21
N2 - BACKGROUND Immunosuppression has undoubtedly raised the overall positive outcomes in the post-operative management of solid organ transplantation. However, long-term exposure to immunosuppression is associated with critical systemic morbidities. De novo malignancies following orthotopic liver transplants (OLTs) are a serious threat in pediatric and adult transplant individuals. Data from different experiences were reported and compared to assess the connection between immunosuppression and de novo malignancies in liver transplant patients. AIM To study the role of immunosuppression on the incidence of de novo malignancies in liver transplant recipients. METHODS A systematic literature examination about de novo malignancies and immunosuppression weaning in adult and pediatric OLT recipients was described in the present review. Worldwide data were collected from highly qualified institutions performing OLTs. Patient follow-up, immunosuppression discontinuation and incidence of de novo malignancies were reported. Likewise, the review assesses the differences in adult and pediatric recipients by describing the adopted immunosuppression regimens and the different type of diagnosed solid and blood malignancy.
AB - BACKGROUND Immunosuppression has undoubtedly raised the overall positive outcomes in the post-operative management of solid organ transplantation. However, long-term exposure to immunosuppression is associated with critical systemic morbidities. De novo malignancies following orthotopic liver transplants (OLTs) are a serious threat in pediatric and adult transplant individuals. Data from different experiences were reported and compared to assess the connection between immunosuppression and de novo malignancies in liver transplant patients. AIM To study the role of immunosuppression on the incidence of de novo malignancies in liver transplant recipients. METHODS A systematic literature examination about de novo malignancies and immunosuppression weaning in adult and pediatric OLT recipients was described in the present review. Worldwide data were collected from highly qualified institutions performing OLTs. Patient follow-up, immunosuppression discontinuation and incidence of de novo malignancies were reported. Likewise, the review assesses the differences in adult and pediatric recipients by describing the adopted immunosuppression regimens and the different type of diagnosed solid and blood malignancy.
KW - Adult liver transplant
KW - Cancer
KW - Clinical operationaltolerance
KW - De novo malignancies
KW - Graft rejection
KW - Immune system
KW - Immunosuppression minimization
KW - Immunosuppression weaning
KW - Pediatric liver transplant
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U2 - 10.3748/wjg.v25.i35.5356
DO - 10.3748/wjg.v25.i35.5356
M3 - Review article
C2 - 31558879
AN - SCOPUS:85072709690
VL - 25
SP - 5356
EP - 5375
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 35
ER -