De novo membranous nephropathy (MN) in kidney allografts. A peculiar form of alloimmune disease?

Claudio Ponticelli, Richard J. Glassock

Research output: Contribution to journalArticlepeer-review

Abstract

De novo membranous nephropathy (MN) is an uncommon complication of kidney transplantation, which shows histological findings similar to those seen in recurrent MN, but with some distinct differences. The clinical presentation may be variable, from asymptomatic to nephrotic proteinuria. The disease may run an indolent course or may have an accelerated course leading to allograft loss. De novo membranous nephropathy (MN) can develop in transplant recipients with viral hepatitis, Alport syndrome, ureteral obstruction, renal infarction, or in conjunction with recurrent IgA nephritis. Histologic signs of allograft rejection are often associated with or can antedate de novo MN. These findings suggest that donor-specific antibodies and antibody-mediated rejection might play a pathogenetic role in some patients with de novo MN. However, signs of rejection were absent in a number of cases, and in some instances the disease developed in recipients of "full house" HLA- matched kidneys. Thus, it seems possible that de novo MN is not because of allograft rejection per se, but is triggered by different injuries that can create an inflammatory environment, activate innate immunity, and expose hidden (cryptic) antigens, probably different from those observed to be involved in idiopathic MN. These events can lead to the production of circulating antibodies and in situ formation of immune complexes (IC) and the morphological lesion of MN.

Original languageEnglish
Pages (from-to)1205-1210
Number of pages6
JournalTransplant International
Volume25
Issue number12
DOIs
Publication statusPublished - Dec 2012

Keywords

  • chronic rejection
  • glomerulonephritis pathogenesis
  • kidney allograft
  • membranous nephropathy
  • proteinuria
  • transplant glomerulonephritis

ASJC Scopus subject areas

  • Transplantation

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