Deactivation of brain areas during self-regulation of slow cortical potentials in seizure patients

Ute Strehl, Tracy Trevorrow, Ralf Veit, Thilo Hinterberger, Boris Kotchoubey, Michael Erb, Niels Birbaumer

Research output: Contribution to journalArticle

Abstract

This study investigates the neurophysiological basis of EEG feedback for patients with epilepsy. Brain areas are identified that become hemodynamically deactivated when epilepsy patients, trained in EEG self-regulation, generate positive slow cortical potentials (SCPs). Five patients were trained in producing positive SCPs, using a training protocol previously established to reduce seizure frequency in patients with drug refractory epilepsy. Patients attempted to produce positive SCP shifts in a functional magnetic resonance imaging (fMRI) scanner. Two patients were able to reliably produce positive SCP shifts. When these successful regulators were prompted to produce positive SCPs, blood oxygen level-dependent (BOLD) response indicated deactivation, in comparison to a control state, around the recording electrode, frontal lobe, and thalamus. Unsuccessful regulators' BOLD response indicated no deactivation in cortical areas proximal to the active electrode. No thalamic deactivation was found in poor regulators. Decreased seizure frequency from SCP training may be the result of positively reinforced inhibition in cortical areas proximal to active electrode placement, the frontal cortex, and the thalamus.

Original languageEnglish
Pages (from-to)85-94
Number of pages10
JournalApplied Psychophysiology Biofeedback
Volume31
Issue number1
DOIs
Publication statusPublished - Mar 2006

Keywords

  • Epilepsy
  • Functional magnetic resonance imaging
  • Neurofeedback
  • Self-regulation
  • Slow cortical potentials

ASJC Scopus subject areas

  • Psychology(all)
  • Clinical Psychology

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    Strehl, U., Trevorrow, T., Veit, R., Hinterberger, T., Kotchoubey, B., Erb, M., & Birbaumer, N. (2006). Deactivation of brain areas during self-regulation of slow cortical potentials in seizure patients. Applied Psychophysiology Biofeedback, 31(1), 85-94. https://doi.org/10.1007/s10484-006-9006-6