Death due to asthma at workplace in a diphenylmethane diisocyanate-sensitized subject

Mauro Carino, Maria Aliani, Carmelo Licitra, Nicola Sarno, Francesco Ioli

Research output: Contribution to journalArticlepeer-review


Total cases of fatal asthma in the occupational setting reported in the literature are reviewed and the case of a 39-year-old foundry worker who died at work is described. A diagnosis of occupational asthma induced by diphenylmethane diisocyanate (MDI) had been assessed 5 years in advance through a 0.005 ppm exposure inhalation challenge. Postmortem microscopic examination of the lung showed epithelial desquamation, eosinophilic/neutrophilic infiltration of the mucosa, dilatation of bronchial vessels, edema, hypertrophy and disarray of smooth muscle. Fatal asthma attack in a MDI-sensitized individual, to our knowledge, has not been previously described.

Original languageEnglish
Pages (from-to)111-113
Number of pages3
Issue number1
Publication statusPublished - Jan 1997


  • Asthma mortality
  • Fatal outcome
  • Isocyanates
  • Occupational asthma

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine


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