Abstract
Total cases of fatal asthma in the occupational setting reported in the literature are reviewed and the case of a 39-year-old foundry worker who died at work is described. A diagnosis of occupational asthma induced by diphenylmethane diisocyanate (MDI) had been assessed 5 years in advance through a 0.005 ppm exposure inhalation challenge. Postmortem microscopic examination of the lung showed epithelial desquamation, eosinophilic/neutrophilic infiltration of the mucosa, dilatation of bronchial vessels, edema, hypertrophy and disarray of smooth muscle. Fatal asthma attack in a MDI-sensitized individual, to our knowledge, has not been previously described.
| Original language | English |
|---|---|
| Pages (from-to) | 111-113 |
| Number of pages | 3 |
| Journal | Respiration |
| Volume | 64 |
| Issue number | 1 |
| Publication status | Published - Jan 1997 |
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Keywords
- Asthma mortality
- Fatal outcome
- Isocyanates
- Occupational asthma
ASJC Scopus subject areas
- Physiology
- Pulmonary and Respiratory Medicine
Cite this
Death due to asthma at workplace in a diphenylmethane diisocyanate-sensitized subject. / Carino, Mauro; Aliani, Maria; Licitra, Carmelo; Sarno, Nicola; Ioli, Francesco.
In: Respiration, Vol. 64, No. 1, 01.1997, p. 111-113.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Death due to asthma at workplace in a diphenylmethane diisocyanate-sensitized subject
AU - Carino, Mauro
AU - Aliani, Maria
AU - Licitra, Carmelo
AU - Sarno, Nicola
AU - Ioli, Francesco
PY - 1997/1
Y1 - 1997/1
N2 - Total cases of fatal asthma in the occupational setting reported in the literature are reviewed and the case of a 39-year-old foundry worker who died at work is described. A diagnosis of occupational asthma induced by diphenylmethane diisocyanate (MDI) had been assessed 5 years in advance through a 0.005 ppm exposure inhalation challenge. Postmortem microscopic examination of the lung showed epithelial desquamation, eosinophilic/neutrophilic infiltration of the mucosa, dilatation of bronchial vessels, edema, hypertrophy and disarray of smooth muscle. Fatal asthma attack in a MDI-sensitized individual, to our knowledge, has not been previously described.
AB - Total cases of fatal asthma in the occupational setting reported in the literature are reviewed and the case of a 39-year-old foundry worker who died at work is described. A diagnosis of occupational asthma induced by diphenylmethane diisocyanate (MDI) had been assessed 5 years in advance through a 0.005 ppm exposure inhalation challenge. Postmortem microscopic examination of the lung showed epithelial desquamation, eosinophilic/neutrophilic infiltration of the mucosa, dilatation of bronchial vessels, edema, hypertrophy and disarray of smooth muscle. Fatal asthma attack in a MDI-sensitized individual, to our knowledge, has not been previously described.
KW - Asthma mortality
KW - Fatal outcome
KW - Isocyanates
KW - Occupational asthma
UR - http://www.scopus.com/inward/record.url?scp=0031014460&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031014460&partnerID=8YFLogxK
M3 - Article
C2 - 9044486
AN - SCOPUS:0031014460
VL - 64
SP - 111
EP - 113
JO - Respiration; international review of thoracic diseases
JF - Respiration; international review of thoracic diseases
SN - 0025-7931
IS - 1
ER -