Death due to asthma at workplace in a diphenylmethane diisocyanate-sensitized subject

Mauro Carino, Maria Aliani, Carmelo Licitra, Nicola Sarno, Francesco Ioli

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Total cases of fatal asthma in the occupational setting reported in the literature are reviewed and the case of a 39-year-old foundry worker who died at work is described. A diagnosis of occupational asthma induced by diphenylmethane diisocyanate (MDI) had been assessed 5 years in advance through a 0.005 ppm exposure inhalation challenge. Postmortem microscopic examination of the lung showed epithelial desquamation, eosinophilic/neutrophilic infiltration of the mucosa, dilatation of bronchial vessels, edema, hypertrophy and disarray of smooth muscle. Fatal asthma attack in a MDI-sensitized individual, to our knowledge, has not been previously described.

Original languageEnglish
Pages (from-to)111-113
Number of pages3
JournalRespiration
Volume64
Issue number1
Publication statusPublished - Jan 1997

Fingerprint

Occupational Asthma
Workplace
Asthma
Inhalation Exposure
Hypertrophy
Smooth Muscle
Dilatation
Autopsy
Edema
Mucous Membrane
Lung
4,4'-diphenylmethane diisocyanate

Keywords

  • Asthma mortality
  • Fatal outcome
  • Isocyanates
  • Occupational asthma

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Carino, M., Aliani, M., Licitra, C., Sarno, N., & Ioli, F. (1997). Death due to asthma at workplace in a diphenylmethane diisocyanate-sensitized subject. Respiration, 64(1), 111-113.

Death due to asthma at workplace in a diphenylmethane diisocyanate-sensitized subject. / Carino, Mauro; Aliani, Maria; Licitra, Carmelo; Sarno, Nicola; Ioli, Francesco.

In: Respiration, Vol. 64, No. 1, 01.1997, p. 111-113.

Research output: Contribution to journalArticle

Carino, M, Aliani, M, Licitra, C, Sarno, N & Ioli, F 1997, 'Death due to asthma at workplace in a diphenylmethane diisocyanate-sensitized subject', Respiration, vol. 64, no. 1, pp. 111-113.
Carino, Mauro ; Aliani, Maria ; Licitra, Carmelo ; Sarno, Nicola ; Ioli, Francesco. / Death due to asthma at workplace in a diphenylmethane diisocyanate-sensitized subject. In: Respiration. 1997 ; Vol. 64, No. 1. pp. 111-113.
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