Death due to asthma at workplace in a diphenylmethane diisocyanate-sensitized subject

Mauro Carino, Maria Aliani, Carmelo Licitra, Nicola Sarno, Francesco Ioli

Research output: Contribution to journalArticle

Abstract

Total cases of fatal asthma in the occupational setting reported in the literature are reviewed and the case of a 39-year-old foundry worker who died at work is described. A diagnosis of occupational asthma induced by diphenylmethane diisocyanate (MDI) had been assessed 5 years in advance through a 0.005 ppm exposure inhalation challenge. Postmortem microscopic examination of the lung showed epithelial desquamation, eosinophilic/neutrophilic infiltration of the mucosa, dilatation of bronchial vessels, edema, hypertrophy and disarray of smooth muscle. Fatal asthma attack in a MDI-sensitized individual, to our knowledge, has not been previously described.

Original languageEnglish
Pages (from-to)111-113
Number of pages3
JournalRespiration
Volume64
Issue number1
Publication statusPublished - Jan 1997

Keywords

  • Asthma mortality
  • Fatal outcome
  • Isocyanates
  • Occupational asthma

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Death due to asthma at workplace in a diphenylmethane diisocyanate-sensitized subject'. Together they form a unique fingerprint.

  • Cite this

    Carino, M., Aliani, M., Licitra, C., Sarno, N., & Ioli, F. (1997). Death due to asthma at workplace in a diphenylmethane diisocyanate-sensitized subject. Respiration, 64(1), 111-113.