Decay of HIV type 1 DNA and development of drug-resistant mutants in patients with primary HIV type 1 infection receiving highly active antiretroviral therapy

Elisabetta Riva, Ferdinando Dianzani, Guido Antonelli, Mauro Pistello, Pasquale Narciso, Gianpiero D'Offizi, Patrizia Isola, Vincenzo Galati, Ombretta Turriziani, Valerio Tozzi, Laura Vincenzi

Research output: Contribution to journalArticlepeer-review

Abstract

The present study was aimed at describing the effect of highly active antiretroviral therapy (HAART) in 10 patients with primary HIV infection (PHI). Clearance rates of HIV RNA and HIV DNA in peripheral blood as well as the preexistence and the emergence of drug-resistant strains of HIV were determined over 52 weeks of treatment. The data indicate that HAART is able to induce a suppression of plasma viral load together with a significant decrease, but not a suppression, of peripheral blood mononuclear cell-associated proviral DNA in PHI subjects. Analysis of drug-resistant strains revealed that three PHI patients, showing a complete virologic response, developed mutations in the pol gene, thus suggesting that a persistent residual virus replication exists despite a sustained suppression of plasma viremia.

Original languageEnglish
Pages (from-to)1599-1604
Number of pages6
JournalAIDS Research and Human Retroviruses
Volume17
Issue number17
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Immunology
  • Virology

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