TY - JOUR
T1 - Decay of HIV type 1 DNA and development of drug-resistant mutants in patients with primary HIV type 1 infection receiving highly active antiretroviral therapy
AU - Riva, Elisabetta
AU - Dianzani, Ferdinando
AU - Antonelli, Guido
AU - Pistello, Mauro
AU - Narciso, Pasquale
AU - D'Offizi, Gianpiero
AU - Isola, Patrizia
AU - Galati, Vincenzo
AU - Turriziani, Ombretta
AU - Tozzi, Valerio
AU - Vincenzi, Laura
PY - 2001
Y1 - 2001
N2 - The present study was aimed at describing the effect of highly active antiretroviral therapy (HAART) in 10 patients with primary HIV infection (PHI). Clearance rates of HIV RNA and HIV DNA in peripheral blood as well as the preexistence and the emergence of drug-resistant strains of HIV were determined over 52 weeks of treatment. The data indicate that HAART is able to induce a suppression of plasma viral load together with a significant decrease, but not a suppression, of peripheral blood mononuclear cell-associated proviral DNA in PHI subjects. Analysis of drug-resistant strains revealed that three PHI patients, showing a complete virologic response, developed mutations in the pol gene, thus suggesting that a persistent residual virus replication exists despite a sustained suppression of plasma viremia.
AB - The present study was aimed at describing the effect of highly active antiretroviral therapy (HAART) in 10 patients with primary HIV infection (PHI). Clearance rates of HIV RNA and HIV DNA in peripheral blood as well as the preexistence and the emergence of drug-resistant strains of HIV were determined over 52 weeks of treatment. The data indicate that HAART is able to induce a suppression of plasma viral load together with a significant decrease, but not a suppression, of peripheral blood mononuclear cell-associated proviral DNA in PHI subjects. Analysis of drug-resistant strains revealed that three PHI patients, showing a complete virologic response, developed mutations in the pol gene, thus suggesting that a persistent residual virus replication exists despite a sustained suppression of plasma viremia.
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U2 - 10.1089/088922201753342004
DO - 10.1089/088922201753342004
M3 - Article
C2 - 11779347
AN - SCOPUS:0035695104
VL - 17
SP - 1599
EP - 1604
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
SN - 0889-2229
IS - 17
ER -