TY - JOUR
T1 - Decay of human immunodeficiency virus type 1 unintegrated DNA containing two long terminal repeats in infected individuals after 3 to 8 years of sustained control of viremia
AU - McDermott, Jennifer L.
AU - Martini, Isabella
AU - Ferrari, Davide
AU - Bertolotti, Francesca
AU - Giacomazzi, Claudio
AU - Murdaca, Giuseppe
AU - Puppo, Francesco
AU - Indiveri, Francesco
AU - Varnier, Oliviero E.
PY - 2005/10
Y1 - 2005/10
N2 - Covert human immunodeficiency virus (HIV) replication was ongoing during the first 3 years of aviremia in 22 patients, as determined by detection of DNA containing two long terminal repeats (2LTR DNA). Although total HIV DNA was detected in 60 2LTR DNA-negative samples, the absence of 2LTR DNA in 90% of patients following 7 to 8 years of highly active antiretroviral therapy suggests suppression of cryptic viral replication.
AB - Covert human immunodeficiency virus (HIV) replication was ongoing during the first 3 years of aviremia in 22 patients, as determined by detection of DNA containing two long terminal repeats (2LTR DNA). Although total HIV DNA was detected in 60 2LTR DNA-negative samples, the absence of 2LTR DNA in 90% of patients following 7 to 8 years of highly active antiretroviral therapy suggests suppression of cryptic viral replication.
UR - http://www.scopus.com/inward/record.url?scp=26944490692&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=26944490692&partnerID=8YFLogxK
U2 - 10.1128/JCM.43.10.5272-5274.2005
DO - 10.1128/JCM.43.10.5272-5274.2005
M3 - Article
C2 - 16207994
AN - SCOPUS:26944490692
VL - 43
SP - 5272
EP - 5274
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
SN - 0095-1137
IS - 10
ER -