Decay of human immunodeficiency virus type 1 unintegrated DNA containing two long terminal repeats in infected individuals after 3 to 8 years of sustained control of viremia

Jennifer L. McDermott, Isabella Martini, Davide Ferrari, Francesca Bertolotti, Claudio Giacomazzi, Giuseppe Murdaca, Francesco Puppo, Francesco Indiveri, Oliviero E. Varnier

Research output: Contribution to journalArticlepeer-review

Abstract

Covert human immunodeficiency virus (HIV) replication was ongoing during the first 3 years of aviremia in 22 patients, as determined by detection of DNA containing two long terminal repeats (2LTR DNA). Although total HIV DNA was detected in 60 2LTR DNA-negative samples, the absence of 2LTR DNA in 90% of patients following 7 to 8 years of highly active antiretroviral therapy suggests suppression of cryptic viral replication.

Original languageEnglish
Pages (from-to)5272-5274
Number of pages3
JournalJournal of Clinical Microbiology
Volume43
Issue number10
DOIs
Publication statusPublished - Oct 2005

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Fingerprint Dive into the research topics of 'Decay of human immunodeficiency virus type 1 unintegrated DNA containing two long terminal repeats in infected individuals after 3 to 8 years of sustained control of viremia'. Together they form a unique fingerprint.

Cite this