Decidual endovascular trophoblast invasion in women with polycystic ovary syndrome: An experimental case-control study

Stefano Palomba, Tiziana Russo, Angela Falbo, Annalisa Di Cello, Giuseppina Amendola, Rosa Mazza, Achille Tolino, Fulvio Zullo, Luigi Tucci, Giovanni Battista La Sala

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Context: Previous experimental and clinical data suggest impaired decidual trophoblast invasion in patients with polycystic ovarian syndrome (PCOS). Objective: Theobjective ofthestudywasto testthehypothesis that decidual endovascular trophoblast invasion in pregnant patients with PCOS is impaired and to clarify the potential mechanisms involved. Design: This was an experimental case-control study. Setting: The study was conducted at the academic Departments of Obstetrics and Gynecology and the Unit of Pathology (Italy). Patients: Forty-five pregnant subjects screened from a wide population ofwomenwaiting for legal pregnancy termination were included in the final analysis. Specifically, 15 pregnant patients with PCOS were enrolled as cases and another 30 age- and body mass index (BMI)-matched healthy pregnant women without any feature of PCOS were enrolled as the controls. Intervention: Interventions included the collection of trophoblastic and decidual tissue at the 12th week of gestation. Main Outcome Measures: Clinical, ultrasonographic, and biochemical data as well as the histological analysis of decidual endovascular trophoblast invasion. Results: The rate of implantation site vessels with endovascular trophoblast invasion (ratio between total number of implantation site vessels and total number of vessels with endovascular trophoblast invasion) and the extent of endovascular trophoblast invasion (proportion between immunoreactive areas to cytokeratin 7 and to CD34) were significantly lower in patients with PCOS compared with healthy non-PCOS controls. Endovascular trophoblast invasion data were significantly and indirectly related to the markers of insulin resistance and testosterone concentrations in PCOS patients. Conclusions: Pregnant patients with PCOS patients have impaired decidual trophoblast invasion. Further studies are needed to evaluate the exact mechanisms through which insulin resistance and hyperandrogenemia exert this effect.

Original languageEnglish
Pages (from-to)2441-2449
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume97
Issue number7
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Polycystic Ovary Syndrome
Trophoblasts
Case-Control Studies
Gynecology
Obstetrics
Insulin
Keratin-7
Pathology
Testosterone
Tissue
Insulin Resistance
Pregnancy
Hospital Obstetrics and Gynecology Department
Italy
Pregnant Women
Body Mass Index
Outcome Assessment (Health Care)
Population

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Decidual endovascular trophoblast invasion in women with polycystic ovary syndrome : An experimental case-control study. / Palomba, Stefano; Russo, Tiziana; Falbo, Angela; Di Cello, Annalisa; Amendola, Giuseppina; Mazza, Rosa; Tolino, Achille; Zullo, Fulvio; Tucci, Luigi; La Sala, Giovanni Battista.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 97, No. 7, 07.2012, p. 2441-2449.

Research output: Contribution to journalArticle

Palomba, Stefano ; Russo, Tiziana ; Falbo, Angela ; Di Cello, Annalisa ; Amendola, Giuseppina ; Mazza, Rosa ; Tolino, Achille ; Zullo, Fulvio ; Tucci, Luigi ; La Sala, Giovanni Battista. / Decidual endovascular trophoblast invasion in women with polycystic ovary syndrome : An experimental case-control study. In: Journal of Clinical Endocrinology and Metabolism. 2012 ; Vol. 97, No. 7. pp. 2441-2449.
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AU - Di Cello, Annalisa

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AU - Mazza, Rosa

AU - Tolino, Achille

AU - Zullo, Fulvio

AU - Tucci, Luigi

AU - La Sala, Giovanni Battista

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AB - Context: Previous experimental and clinical data suggest impaired decidual trophoblast invasion in patients with polycystic ovarian syndrome (PCOS). Objective: Theobjective ofthestudywasto testthehypothesis that decidual endovascular trophoblast invasion in pregnant patients with PCOS is impaired and to clarify the potential mechanisms involved. Design: This was an experimental case-control study. Setting: The study was conducted at the academic Departments of Obstetrics and Gynecology and the Unit of Pathology (Italy). Patients: Forty-five pregnant subjects screened from a wide population ofwomenwaiting for legal pregnancy termination were included in the final analysis. Specifically, 15 pregnant patients with PCOS were enrolled as cases and another 30 age- and body mass index (BMI)-matched healthy pregnant women without any feature of PCOS were enrolled as the controls. Intervention: Interventions included the collection of trophoblastic and decidual tissue at the 12th week of gestation. Main Outcome Measures: Clinical, ultrasonographic, and biochemical data as well as the histological analysis of decidual endovascular trophoblast invasion. Results: The rate of implantation site vessels with endovascular trophoblast invasion (ratio between total number of implantation site vessels and total number of vessels with endovascular trophoblast invasion) and the extent of endovascular trophoblast invasion (proportion between immunoreactive areas to cytokeratin 7 and to CD34) were significantly lower in patients with PCOS compared with healthy non-PCOS controls. Endovascular trophoblast invasion data were significantly and indirectly related to the markers of insulin resistance and testosterone concentrations in PCOS patients. Conclusions: Pregnant patients with PCOS patients have impaired decidual trophoblast invasion. Further studies are needed to evaluate the exact mechanisms through which insulin resistance and hyperandrogenemia exert this effect.

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