Decidual vascular patterns in first-trimester abortions

Yuri Musizzano, Ezio Fulcheri

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In many cases of early spontaneous abortion (ESA), no reasonable etiology can be documented. However, some of these cases show abnormal decidual vessels that could be overlooked when examined on hematoxylin and eosin (H&E) slides alone. Diagnostic accuracy could be improved by the use of a limited histochemical (HC) and immunohistochemical (IHC) panel. We reviewed 1,095 ESAs, selecting 176 cases with abnormal decidual vessels and subclassifying them into three groups on the basis of decidual vascular pattern. Various HC and IHC stainings were performed in order to assess their use in improving diagnostic sensitivity. Histological findings on H&E were recorded and compared to the results obtained with HC and IHC. A variable role in the improvement of morphologic details was demonstrated for all three tested HC stainings (periodic acid-Schiff, Masson's trichrome, Weigert's stain for fibrin) and for two of the IHC markers (smooth muscle actin, human placental lactogen). In many cases of ESA, only compatibility diagnoses can be formulated. However, using a limited panel of HC and IHC stainings, some significant findings can be more reliably reported, allowing the pathologist to acquire confidence in his routine diagnostic work.

Original languageEnglish
Pages (from-to)543-560
Number of pages18
JournalVirchows Archiv
Volume456
Issue number5
DOIs
Publication statusPublished - May 2010

Fingerprint

First Pregnancy Trimester
Blood Vessels
Spontaneous Abortion
Staining and Labeling
Placental Lactogen
Periodic Acid
Hematoxylin
Eosine Yellowish-(YS)
Fibrin
Smooth Muscle
Actins

Keywords

  • Abortion
  • Autoimmune diseases
  • Histopathological diagnosis
  • Luteal defect

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Decidual vascular patterns in first-trimester abortions. / Musizzano, Yuri; Fulcheri, Ezio.

In: Virchows Archiv, Vol. 456, No. 5, 05.2010, p. 543-560.

Research output: Contribution to journalArticle

Musizzano, Yuri ; Fulcheri, Ezio. / Decidual vascular patterns in first-trimester abortions. In: Virchows Archiv. 2010 ; Vol. 456, No. 5. pp. 543-560.
@article{0841442248644a76a17bcf14d959c594,
title = "Decidual vascular patterns in first-trimester abortions",
abstract = "In many cases of early spontaneous abortion (ESA), no reasonable etiology can be documented. However, some of these cases show abnormal decidual vessels that could be overlooked when examined on hematoxylin and eosin (H&E) slides alone. Diagnostic accuracy could be improved by the use of a limited histochemical (HC) and immunohistochemical (IHC) panel. We reviewed 1,095 ESAs, selecting 176 cases with abnormal decidual vessels and subclassifying them into three groups on the basis of decidual vascular pattern. Various HC and IHC stainings were performed in order to assess their use in improving diagnostic sensitivity. Histological findings on H&E were recorded and compared to the results obtained with HC and IHC. A variable role in the improvement of morphologic details was demonstrated for all three tested HC stainings (periodic acid-Schiff, Masson's trichrome, Weigert's stain for fibrin) and for two of the IHC markers (smooth muscle actin, human placental lactogen). In many cases of ESA, only compatibility diagnoses can be formulated. However, using a limited panel of HC and IHC stainings, some significant findings can be more reliably reported, allowing the pathologist to acquire confidence in his routine diagnostic work.",
keywords = "Abortion, Autoimmune diseases, Histopathological diagnosis, Luteal defect",
author = "Yuri Musizzano and Ezio Fulcheri",
year = "2010",
month = "5",
doi = "10.1007/s00428-010-0883-y",
language = "English",
volume = "456",
pages = "543--560",
journal = "Virchows Archiv - A Pathological Anatomy and Histopathology",
issn = "0945-6317",
publisher = "Springer Verlag",
number = "5",

}

TY - JOUR

T1 - Decidual vascular patterns in first-trimester abortions

AU - Musizzano, Yuri

AU - Fulcheri, Ezio

PY - 2010/5

Y1 - 2010/5

N2 - In many cases of early spontaneous abortion (ESA), no reasonable etiology can be documented. However, some of these cases show abnormal decidual vessels that could be overlooked when examined on hematoxylin and eosin (H&E) slides alone. Diagnostic accuracy could be improved by the use of a limited histochemical (HC) and immunohistochemical (IHC) panel. We reviewed 1,095 ESAs, selecting 176 cases with abnormal decidual vessels and subclassifying them into three groups on the basis of decidual vascular pattern. Various HC and IHC stainings were performed in order to assess their use in improving diagnostic sensitivity. Histological findings on H&E were recorded and compared to the results obtained with HC and IHC. A variable role in the improvement of morphologic details was demonstrated for all three tested HC stainings (periodic acid-Schiff, Masson's trichrome, Weigert's stain for fibrin) and for two of the IHC markers (smooth muscle actin, human placental lactogen). In many cases of ESA, only compatibility diagnoses can be formulated. However, using a limited panel of HC and IHC stainings, some significant findings can be more reliably reported, allowing the pathologist to acquire confidence in his routine diagnostic work.

AB - In many cases of early spontaneous abortion (ESA), no reasonable etiology can be documented. However, some of these cases show abnormal decidual vessels that could be overlooked when examined on hematoxylin and eosin (H&E) slides alone. Diagnostic accuracy could be improved by the use of a limited histochemical (HC) and immunohistochemical (IHC) panel. We reviewed 1,095 ESAs, selecting 176 cases with abnormal decidual vessels and subclassifying them into three groups on the basis of decidual vascular pattern. Various HC and IHC stainings were performed in order to assess their use in improving diagnostic sensitivity. Histological findings on H&E were recorded and compared to the results obtained with HC and IHC. A variable role in the improvement of morphologic details was demonstrated for all three tested HC stainings (periodic acid-Schiff, Masson's trichrome, Weigert's stain for fibrin) and for two of the IHC markers (smooth muscle actin, human placental lactogen). In many cases of ESA, only compatibility diagnoses can be formulated. However, using a limited panel of HC and IHC stainings, some significant findings can be more reliably reported, allowing the pathologist to acquire confidence in his routine diagnostic work.

KW - Abortion

KW - Autoimmune diseases

KW - Histopathological diagnosis

KW - Luteal defect

UR - http://www.scopus.com/inward/record.url?scp=77952514413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952514413&partnerID=8YFLogxK

U2 - 10.1007/s00428-010-0883-y

DO - 10.1007/s00428-010-0883-y

M3 - Article

C2 - 20157826

AN - SCOPUS:77952514413

VL - 456

SP - 543

EP - 560

JO - Virchows Archiv - A Pathological Anatomy and Histopathology

JF - Virchows Archiv - A Pathological Anatomy and Histopathology

SN - 0945-6317

IS - 5

ER -