Decision-making abilities in patients with frontal low-grade glioma

Giulia Mattavelli, Alessandra Casarotti, Matteo Forgiarini, Marco Riva, Lorenzo Bello, Costanza Papagno

Research output: Contribution to journalArticle

Abstract

Decisions in daily life are often quite complex, especially when one has to decide about his/her own health, as it is the case for patients with brain tumours. The integrity of the prefrontal cortex (and of the orbito-frontal in particular) is crucial in humans for practical decision-making. We investigated decision-making in 22 right-handed patients with a left frontal low-grade glioma, by means of a more complex, computerized version of the Iowa gambling task and we compared their performance with that of 26 neurologically-unimpaired subjects. After the experiment, we also administered a questionnaire to evaluate subjects' conscious comprehension level of the task and two self-report scales to verify potential effects of individual personality differences. Patients chose significantly less cards than controls from the advantageous deck, without modifying their behaviour over time, and this correlated with abstract reasoning abilities. In both groups, level of comprehension, significantly affected performance. An improvement was found post-surgery. In conclusion, the performance in the Gambling Task suggests that patients with left frontal low-grade gliomas can be impaired in decision-making, apparently requiring more time to understand the task: therefore, a particular attention and care should be taken to explain risks and consequences of his/her illness and treatment in order to obtain an informed decision from the patient.

Original languageEnglish
Pages (from-to)59-67
Number of pages9
JournalJournal of Neuro-Oncology
Volume110
Issue number1
DOIs
Publication statusPublished - Oct 2012

Keywords

  • Decision-making
  • Gambling task
  • Low-grade glioma
  • Prefrontal cortex

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neurology

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