Modello decisionale per l'adozione del vaccino antivaricella: una sfida di fattibilità

Translated title of the contribution: Decisional framework for varicella vaccine: Challenges in the face of opportunity

Marien González-Lorenzo, Marcello Tirani, Alessandra Piatti, Liliana Coppola, Maria Gramegna, Francesca Ruggiero, Francesco Auxilia, Lorenzo Moja

Research output: Contribution to journalArticlepeer-review


Introduction: Decision makers adopt interventions, including vaccines, which are most beneficial to populations. A transparent, unbiased, and comprehensive framework based on evidence-based criteria is a promising tool to guide decision-making on vaccine adoption: we developed a multi-dimensional framework conceived from the DECIDE - Evidence to decision Framework (EtD framework). We validated the framework by conducting a real data and evidence set collection on varicella vaccination and tested it with a multidisciplinary group. Methods. The EtD framework presented evidence concerning the varicella vaccination organized in six dimensions: Burden of disease, Vaccine characteristics and impact of immunization program, Values and preferences, Resource use, Equity and Feasibility. Two reviewers completed each dimension with information about varicella vaccine. A multidisciplinary group of 42 participants were asked to evaluate the information in the framework, decide whether to introduce varicella vaccine in the national immunization program, assess the usefulness, and propose some impovements of the decision-making tool. Results. From 33 responders (79%) out of 42, 61% supported the adoption of the varicella vaccine as part of the national immunization program. A half (50%) favored the monovalent vaccine while the other half chose the tetravalent vaccine. About 90% of responders found information in the EtD framework comprehensive, easy to understand, and presented in a way that helped make decisions. Conclusions. Complete and transparent information are welcome. The EtD identified a situation of important divergences between policy makers regarding the introduction and the choice of vaccine. In our case study, for example, a third of the multidisciplinary group did not recommend the adoption of varicella vaccine.

Translated title of the contributionDecisional framework for varicella vaccine: Challenges in the face of opportunity
Original languageItalian
Pages (from-to)84-107
Number of pages24
JournalRecenti Progressi in Medicina
Issue number2
Publication statusPublished - Feb 1 2016

ASJC Scopus subject areas

  • Medicine(all)


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