Decoys and regulatory "receptors" of the il-1/toll-like receptor superfamily

Cecilia Garlanda; Federica Riva; Eduardo Bonavita; Stefania Gentile; Alberto Mantovani

doi:10.3389/fimmu.2013.00180

Decoys and regulatory "receptors" of the il-1/toll-like receptor superfamily

Cecilia Garlanda, Federica Riva, Eduardo Bonavita, Stefania Gentile, Alberto Mantovani

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signaling molecules and negative regulators. The latter include decoy receptors (IL-1RII; IL- 18BP) and "receptors" with regulatory function (TIR8/SIGIRR; IL-1RAcPb; DIGIRR). Structural considerations suggest that also TIGIRR-1 and IL-1RAPL may have regulatory function. The presence of multiple pathways of negative regulation of members of the IL-1/IL-1R family emphasizes the need for a tight control of members of this fundamental system.

Original language	English
Article number	Article 180
Journal	Frontiers in Immunology
Volume	4
Issue number	JUL
DOIs	https://doi.org/10.3389/fimmu.2013.00180
Publication status	Published - 2013

Keywords

Cytokine
Decoy receptor
Inflammation
Interleukin-1

ASJC Scopus subject areas

Immunology
Immunology and Allergy

Access to Document

10.3389/fimmu.2013.00180

Cite this

@article{d2126941b5024defbacca6836fe95221,

title = "Decoys and regulatory {"}receptors{"} of the il-1/toll-like receptor superfamily",

abstract = "Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signaling molecules and negative regulators. The latter include decoy receptors (IL-1RII; IL- 18BP) and {"}receptors{"} with regulatory function (TIR8/SIGIRR; IL-1RAcPb; DIGIRR). Structural considerations suggest that also TIGIRR-1 and IL-1RAPL may have regulatory function. The presence of multiple pathways of negative regulation of members of the IL-1/IL-1R family emphasizes the need for a tight control of members of this fundamental system.",

keywords = "Cytokine, Decoy receptor, Inflammation, Interleukin-1",

author = "Cecilia Garlanda and Federica Riva and Eduardo Bonavita and Stefania Gentile and Alberto Mantovani",

year = "2013",

doi = "10.3389/fimmu.2013.00180",

language = "English",

volume = "4",

journal = "Frontiers in Immunology",

issn = "1664-3224",

publisher = "Frontiers Media S.A.",

number = "JUL",

}

TY - JOUR

T1 - Decoys and regulatory "receptors" of the il-1/toll-like receptor superfamily

AU - Garlanda, Cecilia

AU - Riva, Federica

AU - Bonavita, Eduardo

AU - Gentile, Stefania

AU - Mantovani, Alberto

PY - 2013

Y1 - 2013

N2 - Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signaling molecules and negative regulators. The latter include decoy receptors (IL-1RII; IL- 18BP) and "receptors" with regulatory function (TIR8/SIGIRR; IL-1RAcPb; DIGIRR). Structural considerations suggest that also TIGIRR-1 and IL-1RAPL may have regulatory function. The presence of multiple pathways of negative regulation of members of the IL-1/IL-1R family emphasizes the need for a tight control of members of this fundamental system.

AB - Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signaling molecules and negative regulators. The latter include decoy receptors (IL-1RII; IL- 18BP) and "receptors" with regulatory function (TIR8/SIGIRR; IL-1RAcPb; DIGIRR). Structural considerations suggest that also TIGIRR-1 and IL-1RAPL may have regulatory function. The presence of multiple pathways of negative regulation of members of the IL-1/IL-1R family emphasizes the need for a tight control of members of this fundamental system.

KW - Cytokine

KW - Decoy receptor

KW - Inflammation

KW - Interleukin-1

UR - http://www.scopus.com/inward/record.url?scp=84883689160&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883689160&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2013.00180

DO - 10.3389/fimmu.2013.00180

M3 - Article

C2 - 23847621

AN - SCOPUS:84883689160

VL - 4

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

IS - JUL

M1 - Article 180

ER -

Decoys and regulatory "receptors" of the il-1/toll-like receptor superfamily

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this