Abstract
Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signaling molecules and negative regulators. The latter include decoy receptors (IL-1RII; IL- 18BP) and "receptors" with regulatory function (TIR8/SIGIRR; IL-1RAcPb; DIGIRR). Structural considerations suggest that also TIGIRR-1 and IL-1RAPL may have regulatory function. The presence of multiple pathways of negative regulation of members of the IL-1/IL-1R family emphasizes the need for a tight control of members of this fundamental system.
Original language | English |
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Article number | Article 180 |
Journal | Frontiers in Immunology |
Volume | 4 |
Issue number | JUL |
DOIs | |
Publication status | Published - 2013 |
Keywords
- Cytokine
- Decoy receptor
- Inflammation
- Interleukin-1
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy