Abstract
Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signaling molecules and negative regulators. The latter include decoy receptors (IL-1RII; IL- 18BP) and "receptors" with regulatory function (TIR8/SIGIRR; IL-1RAcPb; DIGIRR). Structural considerations suggest that also TIGIRR-1 and IL-1RAPL may have regulatory function. The presence of multiple pathways of negative regulation of members of the IL-1/IL-1R family emphasizes the need for a tight control of members of this fundamental system.
| Original language | English |
|---|---|
| Article number | Article 180 |
| Journal | Frontiers in Immunology |
| Volume | 4 |
| Issue number | JUL |
| DOIs | |
| Publication status | Published - 2013 |
Keywords
- Cytokine
- Decoy receptor
- Inflammation
- Interleukin-1
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
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Garlanda, C., Riva, F., Bonavita, E., Gentile, S., & Mantovani, A. (2013). Decoys and regulatory "receptors" of the il-1/toll-like receptor superfamily. Frontiers in Immunology, 4(JUL), [Article 180]. https://doi.org/10.3389/fimmu.2013.00180