Decoys and regulatory "receptors" of the il-1/toll-like receptor superfamily

Cecilia Garlanda, Federica Riva, Eduardo Bonavita, Stefania Gentile, Alberto Mantovani

Research output: Contribution to journalArticlepeer-review


Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signaling molecules and negative regulators. The latter include decoy receptors (IL-1RII; IL- 18BP) and "receptors" with regulatory function (TIR8/SIGIRR; IL-1RAcPb; DIGIRR). Structural considerations suggest that also TIGIRR-1 and IL-1RAPL may have regulatory function. The presence of multiple pathways of negative regulation of members of the IL-1/IL-1R family emphasizes the need for a tight control of members of this fundamental system.

Original languageEnglish
Article numberArticle 180
JournalFrontiers in Immunology
Issue numberJUL
Publication statusPublished - 2013


  • Cytokine
  • Decoy receptor
  • Inflammation
  • Interleukin-1

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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