Decoys and regulatory "receptors" of the il-1/toll-like receptor superfamily

Cecilia Garlanda; Federica Riva; Eduardo Bonavita; Stefania Gentile; Alberto Mantovani

doi:10.3389/fimmu.2013.00180

Decoys and regulatory "receptors" of the il-1/toll-like receptor superfamily

Cecilia Garlanda, Federica Riva, Eduardo Bonavita, Stefania Gentile, Alberto Mantovani

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signaling molecules and negative regulators. The latter include decoy receptors (IL-1RII; IL- 18BP) and "receptors" with regulatory function (TIR8/SIGIRR; IL-1RAcPb; DIGIRR). Structural considerations suggest that also TIGIRR-1 and IL-1RAPL may have regulatory function. The presence of multiple pathways of negative regulation of members of the IL-1/IL-1R family emphasizes the need for a tight control of members of this fundamental system.

Original language	English
Article number	Article 180
Journal	Frontiers in Immunology
Volume	4
Issue number	JUL
DOIs	https://doi.org/10.3389/fimmu.2013.00180
Publication status	Published - 2013

Keywords

Cytokine
Decoy receptor
Inflammation
Interleukin-1

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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10.3389/fimmu.2013.00180

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AU - Mantovani, Alberto

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Decoys and regulatory "receptors" of the il-1/toll-like receptor superfamily

Abstract

Keywords

ASJC Scopus subject areas

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