Decrease in urokinase-type plasminogen activator (u-PA) levels in patients with non-insulin dependent diabetes mellitus

K. Krekora, E. Vitacolonna, A. Di Castelnuovo, A. D'Orazio, D. De Lucia, G. Dooijewaard, F. Capani, M. B. Donati, L. Lacoviello

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The objective of the study was to investigate the activity and antigen levels of u-PA in non-insulin dependent diabetes mellitus (NIDDM) patients, and their changes after venous stasis. A cross-sectional case-control study was carried out in the out-patient diabetelogy clinical unit of the General Hospital in Pescara, Italy. Fifty-nine unselected NIDDM patients (23 females and 36 males; mean age 63 ± 10, with diabetes definition by WHO criteria) were studied. A group of 50 subjects, age matched (age 58 ± 9, 42 males, 8 females), without a history of diabetes, were consecutively recruited among healthy relatives of patients admitted to the hospital for surgical interventions to serve as a control group. The levels of both u-PA activity (scu-PA) and antigen (u-PA Ag) were significantly lower in NIDDM patients compared to controls, in contrast, t-PA, PAI-1 antigan and PAI activity levels were increased in NIDDM patients. There was no change in u-PA levels (bath activity and antigen) after venous stasis, while t-PA levels were significantly increased. There was no difference in u-PA (both activity and antigen) and in t-PA levels between male and female patients. However, fibrinogen levels were lower and PAI-1, both antigen and activity, was higher in men than in women. No difference was found between patients with and without macrovascular complications in the parametres studied. Besides changes in t-PA and PAI-1 levels, NIDDM is also characterized by a decrease in u-PA activity and antigen levels. Such impairment of the fibrinolytic system, together with the increase in fibrinogen levels, could contribute to the prothrombotic condition peculiar to these patients.

Original languageEnglish
Pages (from-to)215-219
Number of pages5
JournalFibrinolysis and Proteolysis
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Hematology


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