Decrease of food intake by quipazine in the rat: relation to serotoninergic receptor stimulation

Since 5-HT appears to be involved in the regulation of food intake in various animal species as well as in the anorectic activity of fenfluramine, it was speculated that quipazine might affect the food intake of rats as a consequence of its ability to mimic 5-HT activity. The present experiments were undertaken in an attempt to verify this hypothesis. The present data further support the hypothesis for an involvement of central 5-HT in the mechanisms regulating food intake and suggest that quipazine may be an additional useful tool to investigate such mechanisms.