Decrease of immunoreactive catalase protein in specific areas of ageing rat brain

Maria R. Ciriolo, Maria R. Marasco, Michelangelo Iannone, Giuseppe Nisticò, Giuseppe Rotilio

Research output: Contribution to journalArticle

Abstract

The activity of catalase, the main enzyme responsible for detoxification against hydrogen peroxide, decreases in specific brain areas of aged rats. The reduction of enzyme activity appears to be the consequence of a decreased protein expression rather than an impaired function of the native enzyme. In fact, diminution of the immunoreactive protein parallels enzyme activity decrease. Since the extent of decrease of both activity and protein content was observed to be area dependent, we hypothesise that this phenomenon may underlie, at least in part, the increased susceptibility of specific brain regions to oxidative insults observed in pathological situations related to ageing.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalNeuroscience Letters
Volume228
Issue number1
DOIs
Publication statusPublished - May 30 1997

Keywords

  • Ageing
  • Catalase
  • Immunoreactive protein
  • Neurodegeneration
  • Rat brain

ASJC Scopus subject areas

  • Neuroscience(all)

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