Decrease of methicillin resistant Staphylococcus aureus prevalence after introduction of a surgical antibiotic prophylaxis protocol in an Italian hospital

Emanuele Nicastri, Sebastiano Leone, Nicola Petrosillo, Milva Ballardini, Claudio Pisanelli, Patrizia Magrini, Franco Cerquetani, Giuseppe Ippolito, Emma Comandini, Pasquale Narciso, Marcello Meledandri

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The use of antimicrobials is an important factor contributing to the emergence of antibiotic resistance. The goal of our study was to evaluate the impact of the introduction of an antibiotic surgical prophylaxis protocol on the prevalence of methicillin resistant Staphylococcus aureus (MRSA) infections in a tertiary care hospital. The protocol of surgical antibiotic prophylaxis was designed by a multidisciplinary team and was implemented in December 2001. Between January 2002 and December 2002, pharmacy, laboratory and active surveillance-records were prospectively reviewed to calculate prevalence rates of defined daily doses (DDD), microorganism isolation and health-care related infections. A progressive decrease from 1.58 to 0.56 of MRSA isolations per 1000 patient-days and from 76.4% to 29.4% MRSA prevalence rate was reported (prd generation cephalosporins (r=0.90; prd generation cephalosporin use was an effective strategy to reduce the MRSA infection rate and was associated with the reduction of the overall expenditure for antibiotics in the hospital.

Original languageEnglish
Pages (from-to)519-525
Number of pages7
JournalNew Microbiologica
Volume31
Issue number4
Publication statusPublished - Oct 2008

Fingerprint

Antibiotic Prophylaxis
Methicillin-Resistant Staphylococcus aureus
Cephalosporins
Infection
Tertiary Healthcare
Microbial Drug Resistance
Health Expenditures
Tertiary Care Centers
Anti-Bacterial Agents
Delivery of Health Care

Keywords

  • Antibiotic policy
  • Antibiotic surgical prophylaxis
  • Cephalosporins
  • Hospital infection control policy
  • MRSA incidence

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Decrease of methicillin resistant Staphylococcus aureus prevalence after introduction of a surgical antibiotic prophylaxis protocol in an Italian hospital. / Nicastri, Emanuele; Leone, Sebastiano; Petrosillo, Nicola; Ballardini, Milva; Pisanelli, Claudio; Magrini, Patrizia; Cerquetani, Franco; Ippolito, Giuseppe; Comandini, Emma; Narciso, Pasquale; Meledandri, Marcello.

In: New Microbiologica, Vol. 31, No. 4, 10.2008, p. 519-525.

Research output: Contribution to journalArticle

Nicastri, E, Leone, S, Petrosillo, N, Ballardini, M, Pisanelli, C, Magrini, P, Cerquetani, F, Ippolito, G, Comandini, E, Narciso, P & Meledandri, M 2008, 'Decrease of methicillin resistant Staphylococcus aureus prevalence after introduction of a surgical antibiotic prophylaxis protocol in an Italian hospital', New Microbiologica, vol. 31, no. 4, pp. 519-525.
Nicastri, Emanuele ; Leone, Sebastiano ; Petrosillo, Nicola ; Ballardini, Milva ; Pisanelli, Claudio ; Magrini, Patrizia ; Cerquetani, Franco ; Ippolito, Giuseppe ; Comandini, Emma ; Narciso, Pasquale ; Meledandri, Marcello. / Decrease of methicillin resistant Staphylococcus aureus prevalence after introduction of a surgical antibiotic prophylaxis protocol in an Italian hospital. In: New Microbiologica. 2008 ; Vol. 31, No. 4. pp. 519-525.
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