Abstract
Aim. Animal studies suggest an interference of dobutamine on [ 99mTc]sestamibi uptake. In this study dobutamine was compared to dipyridamole rest-stress [99mTc]sestamibi uptake ratio (UR). Methods. Twenty-five patients with suspect coronary artery disease (CAD) underwent rest, dobutamine, and dipyridamole [99mTc]sestamibi SPECT at 24-h intervals and coronary angiography. UR was calculated separately for each coronary territory considering injected dose and acquisition delay. Results. There were 38 CAD territories in 20 patients. On a patient basis, dipyridamole SPECT sensitivity was 85%, versus 70% for dobutamine. On a territory basis, sensitivity was 66% versus 42% (P99mTc]sestamibi uptake underestimates the blood flow heterogeneity induced by dobutamine more than that produced by dipyridamole.
| Original language | English |
|---|---|
| Pages (from-to) | 671-677 |
| Number of pages | 7 |
| Journal | Quarterly Journal of Nuclear Medicine and Molecular Imaging |
| Volume | 53 |
| Issue number | 6 |
| Publication status | Published - Dec 2009 |
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Keywords
- Coronary artery disease
- Dipyridamole
- Dobutamine
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Decreased [99mTc]Sestamibi uptake with dobutamine versus dipyridamole stress. / Sciagrà, R.; Zoccarato, O.; Bisi, G.; Pupi, A.
In: Quarterly Journal of Nuclear Medicine and Molecular Imaging, Vol. 53, No. 6, 12.2009, p. 671-677.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Decreased [99mTc]Sestamibi uptake with dobutamine versus dipyridamole stress
AU - Sciagrà, R.
AU - Zoccarato, O.
AU - Bisi, G.
AU - Pupi, A.
PY - 2009/12
Y1 - 2009/12
N2 - Aim. Animal studies suggest an interference of dobutamine on [ 99mTc]sestamibi uptake. In this study dobutamine was compared to dipyridamole rest-stress [99mTc]sestamibi uptake ratio (UR). Methods. Twenty-five patients with suspect coronary artery disease (CAD) underwent rest, dobutamine, and dipyridamole [99mTc]sestamibi SPECT at 24-h intervals and coronary angiography. UR was calculated separately for each coronary territory considering injected dose and acquisition delay. Results. There were 38 CAD territories in 20 patients. On a patient basis, dipyridamole SPECT sensitivity was 85%, versus 70% for dobutamine. On a territory basis, sensitivity was 66% versus 42% (P99mTc]sestamibi uptake underestimates the blood flow heterogeneity induced by dobutamine more than that produced by dipyridamole.
AB - Aim. Animal studies suggest an interference of dobutamine on [ 99mTc]sestamibi uptake. In this study dobutamine was compared to dipyridamole rest-stress [99mTc]sestamibi uptake ratio (UR). Methods. Twenty-five patients with suspect coronary artery disease (CAD) underwent rest, dobutamine, and dipyridamole [99mTc]sestamibi SPECT at 24-h intervals and coronary angiography. UR was calculated separately for each coronary territory considering injected dose and acquisition delay. Results. There were 38 CAD territories in 20 patients. On a patient basis, dipyridamole SPECT sensitivity was 85%, versus 70% for dobutamine. On a territory basis, sensitivity was 66% versus 42% (P99mTc]sestamibi uptake underestimates the blood flow heterogeneity induced by dobutamine more than that produced by dipyridamole.
KW - Coronary artery disease
KW - Dipyridamole
KW - Dobutamine
UR - http://www.scopus.com/inward/record.url?scp=77949819505&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949819505&partnerID=8YFLogxK
M3 - Article
C2 - 20016457
AN - SCOPUS:77949819505
VL - 53
SP - 671
EP - 677
JO - Quarterly Journal of Nuclear Medicine and Molecular Imaging
JF - Quarterly Journal of Nuclear Medicine and Molecular Imaging
SN - 1824-4785
IS - 6
ER -