Abstract
Aim. Animal studies suggest an interference of dobutamine on [ 99mTc]sestamibi uptake. In this study dobutamine was compared to dipyridamole rest-stress [99mTc]sestamibi uptake ratio (UR). Methods. Twenty-five patients with suspect coronary artery disease (CAD) underwent rest, dobutamine, and dipyridamole [99mTc]sestamibi SPECT at 24-h intervals and coronary angiography. UR was calculated separately for each coronary territory considering injected dose and acquisition delay. Results. There were 38 CAD territories in 20 patients. On a patient basis, dipyridamole SPECT sensitivity was 85%, versus 70% for dobutamine. On a territory basis, sensitivity was 66% versus 42% (P99mTc]sestamibi uptake underestimates the blood flow heterogeneity induced by dobutamine more than that produced by dipyridamole.
Original language | English |
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Pages (from-to) | 671-677 |
Number of pages | 7 |
Journal | Quarterly Journal of Nuclear Medicine and Molecular Imaging |
Volume | 53 |
Issue number | 6 |
Publication status | Published - Dec 2009 |
Keywords
- Coronary artery disease
- Dipyridamole
- Dobutamine
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging