Decreased [99mTc]Sestamibi uptake with dobutamine versus dipyridamole stress

R. Sciagrà, O. Zoccarato, G. Bisi, A. Pupi

Research output: Contribution to journalArticlepeer-review


Aim. Animal studies suggest an interference of dobutamine on [ 99mTc]sestamibi uptake. In this study dobutamine was compared to dipyridamole rest-stress [99mTc]sestamibi uptake ratio (UR). Methods. Twenty-five patients with suspect coronary artery disease (CAD) underwent rest, dobutamine, and dipyridamole [99mTc]sestamibi SPECT at 24-h intervals and coronary angiography. UR was calculated separately for each coronary territory considering injected dose and acquisition delay. Results. There were 38 CAD territories in 20 patients. On a patient basis, dipyridamole SPECT sensitivity was 85%, versus 70% for dobutamine. On a territory basis, sensitivity was 66% versus 42% (P99mTc]sestamibi uptake underestimates the blood flow heterogeneity induced by dobutamine more than that produced by dipyridamole.

Original languageEnglish
Pages (from-to)671-677
Number of pages7
JournalQuarterly Journal of Nuclear Medicine and Molecular Imaging
Issue number6
Publication statusPublished - Dec 2009


  • Coronary artery disease
  • Dipyridamole
  • Dobutamine

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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