Decreased antithrombin III activity in diabetes may be due to non-enzymatic glycosylation - A preliminary report

A. Ceriello, P. Dello Russo, C. Zuccotti, A. Florio, S. Nazzaro, C. Pietrantuono, G. B. Rosato

Research output: Contribution to journalArticle

Abstract

Antithrombin III activity was moderately but significantly decreased in insulin dependent diabetics (p <0.005), while no difference has been found between the diabetic (n = 25) and control groups (n = 22) in antithrombin III plasma concentration. Moreover, antithrombin III activity was inversely correlated with glycosylated plasma proteins (r = -0.57; p <0.01). These data show that in diabetes there is a depressed biological activity of antithrombin III and suggest that this reflects nonenzymatic glycosylation of antithrombin III protein.

Original languageEnglish
Pages (from-to)633-634
Number of pages2
JournalThrombosis and Haemostasis
Volume50
Issue number3
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Hematology

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    Ceriello, A., Dello Russo, P., Zuccotti, C., Florio, A., Nazzaro, S., Pietrantuono, C., & Rosato, G. B. (1983). Decreased antithrombin III activity in diabetes may be due to non-enzymatic glycosylation - A preliminary report. Thrombosis and Haemostasis, 50(3), 633-634.