Decreased antithrombin III activity in diabetes may be due to non-enzymatic glycosylation - A preliminary report

A. Ceriello, P. Dello Russo, C. Zuccotti, A. Florio, S. Nazzaro, C. Pietrantuono, G. B. Rosato

Research output: Contribution to journalArticlepeer-review

Abstract

Antithrombin III activity was moderately but significantly decreased in insulin dependent diabetics (p <0.005), while no difference has been found between the diabetic (n = 25) and control groups (n = 22) in antithrombin III plasma concentration. Moreover, antithrombin III activity was inversely correlated with glycosylated plasma proteins (r = -0.57; p <0.01). These data show that in diabetes there is a depressed biological activity of antithrombin III and suggest that this reflects nonenzymatic glycosylation of antithrombin III protein.

Original languageEnglish
Pages (from-to)633-634
Number of pages2
JournalThrombosis and Haemostasis
Volume50
Issue number3
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Hematology

Fingerprint

Dive into the research topics of 'Decreased antithrombin III activity in diabetes may be due to non-enzymatic glycosylation - A preliminary report'. Together they form a unique fingerprint.

Cite this