Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy

Antonella Isgrò; Ivano Mezzaroma; Alessandro Aiuti; Alessandra Fantauzzi; Marcello Pinti; Andrea Cossarizza; Fernando Aiuti

doi:10.1097/00002030-200406180-00013

Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy

Antonella Isgrò, Ivano Mezzaroma, Alessandro Aiuti, Alessandra Fantauzzi, Marcello Pinti, Andrea Cossarizza, Fernando Aiuti

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.

Original language	English
Pages (from-to)	1335-1337
Number of pages	3
Journal	AIDS (London, England)
Volume	18
Issue number	9
DOIs	https://doi.org/10.1097/00002030-200406180-00013
Publication status	Published - Jun 18 2004

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1097/00002030-200406180-00013

Fingerprint Dive into the research topics of 'Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy'. Together they form a unique fingerprint.

Cite this

Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy. / Isgrò, Antonella; Mezzaroma, Ivano; Aiuti, Alessandro; Fantauzzi, Alessandra; Pinti, Marcello; Cossarizza, Andrea; Aiuti, Fernando.

In: AIDS (London, England), Vol. 18, No. 9, 18.06.2004, p. 1335-1337.

Research output: Contribution to journal › Article › peer-review

@article{c5f4cde89610477b9b04b726b68fb228,

title = "Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy",

abstract = "Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.",

author = "Antonella Isgr{\`o} and Ivano Mezzaroma and Alessandro Aiuti and Alessandra Fantauzzi and Marcello Pinti and Andrea Cossarizza and Fernando Aiuti",

year = "2004",

month = jun,

day = "18",

doi = "10.1097/00002030-200406180-00013",

language = "English",

volume = "18",

pages = "1335--1337",

journal = "AIDS",

issn = "0269-9370",

publisher = "NLM (Medline)",

number = "9",

}

TY - JOUR

T1 - Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy

AU - Isgrò, Antonella

AU - Mezzaroma, Ivano

AU - Aiuti, Alessandro

AU - Fantauzzi, Alessandra

AU - Pinti, Marcello

AU - Cossarizza, Andrea

AU - Aiuti, Fernando

PY - 2004/6/18

Y1 - 2004/6/18

N2 - Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.

AB - Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.

UR - http://www.scopus.com/inward/record.url?scp=3042552161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042552161&partnerID=8YFLogxK

U2 - 10.1097/00002030-200406180-00013

DO - 10.1097/00002030-200406180-00013

M3 - Article

C2 - 15362667

AN - SCOPUS:3042552161

VL - 18

SP - 1335

EP - 1337

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 9

ER -