Abstract
Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.
Original language | English |
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Pages (from-to) | 1335-1337 |
Number of pages | 3 |
Journal | AIDS (London, England) |
Volume | 18 |
Issue number | 9 |
DOIs | |
Publication status | Published - Jun 18 2004 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology