Abstract
Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.
| Original language | English |
|---|---|
| Pages (from-to) | 1335-1337 |
| Number of pages | 3 |
| Journal | AIDS (London, England) |
| Volume | 18 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Jun 18 2004 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy. / Isgrò, Antonella; Mezzaroma, Ivano; Aiuti, Alessandro; Fantauzzi, Alessandra; Pinti, Marcello; Cossarizza, Andrea; Aiuti, Fernando.
In: AIDS (London, England), Vol. 18, No. 9, 18.06.2004, p. 1335-1337.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy
AU - Isgrò, Antonella
AU - Mezzaroma, Ivano
AU - Aiuti, Alessandro
AU - Fantauzzi, Alessandra
AU - Pinti, Marcello
AU - Cossarizza, Andrea
AU - Aiuti, Fernando
PY - 2004/6/18
Y1 - 2004/6/18
N2 - Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.
AB - Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.
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UR - http://www.scopus.com/inward/citedby.url?scp=3042552161&partnerID=8YFLogxK
U2 - 10.1097/00002030-200406180-00013
DO - 10.1097/00002030-200406180-00013
M3 - Article
VL - 18
SP - 1335
EP - 1337
JO - AIDS
JF - AIDS
SN - 0269-9370
IS - 9
ER -