Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy

Antonella Isgrò, Ivano Mezzaroma, Alessandro Aiuti, Alessandra Fantauzzi, Marcello Pinti, Andrea Cossarizza, Fernando Aiuti

Research output: Contribution to journalArticle

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Abstract

Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.

Original languageEnglish
Pages (from-to)1335-1337
Number of pages3
JournalAIDS (London, England)
Volume18
Issue number9
DOIs
Publication statusPublished - Jun 18 2004

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Highly Active Antiretroviral Therapy
Bone Marrow Cells
HIV-1
Stem Cells
Apoptosis
Hematopoiesis
HIV Infections
Bone Marrow
Cytokines

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy. / Isgrò, Antonella; Mezzaroma, Ivano; Aiuti, Alessandro; Fantauzzi, Alessandra; Pinti, Marcello; Cossarizza, Andrea; Aiuti, Fernando.

In: AIDS (London, England), Vol. 18, No. 9, 18.06.2004, p. 1335-1337.

Research output: Contribution to journalArticle

Isgrò, Antonella ; Mezzaroma, Ivano ; Aiuti, Alessandro ; Fantauzzi, Alessandra ; Pinti, Marcello ; Cossarizza, Andrea ; Aiuti, Fernando. / Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy. In: AIDS (London, England). 2004 ; Vol. 18, No. 9. pp. 1335-1337.
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