Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy

Antonella Isgrò; Ivano Mezzaroma; Alessandro Aiuti; Alessandra Fantauzzi; Marcello Pinti; Andrea Cossarizza; Fernando Aiuti

doi:10.1097/00002030-200406180-00013

Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy

Antonella Isgrò, Ivano Mezzaroma, Alessandro Aiuti, Alessandra Fantauzzi, Marcello Pinti, Andrea Cossarizza, Fernando Aiuti

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.

Original language	English
Pages (from-to)	1335-1337
Number of pages	3
Journal	AIDS (London, England)
Volume	18
Issue number	9
DOIs	https://doi.org/10.1097/00002030-200406180-00013
Publication status	Published - Jun 18 2004

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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abstract = "Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.",

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T1 - Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy

AU - Isgrò, Antonella

AU - Mezzaroma, Ivano

AU - Aiuti, Alessandro

AU - Fantauzzi, Alessandra

AU - Pinti, Marcello

AU - Cossarizza, Andrea

AU - Aiuti, Fernando

PY - 2004/6/18

Y1 - 2004/6/18

N2 - Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.

AB - Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.

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JO - AIDS

JF - AIDS

SN - 0269-9370

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Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy

Abstract

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