Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy

Antonella Isgrò; Ivano Mezzaroma; Alessandro Aiuti; Alessandra Fantauzzi; Marcello Pinti; Andrea Cossarizza; Fernando Aiuti

doi:10.1097/00002030-200406180-00013

Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy

Antonella Isgrò, Ivano Mezzaroma, Alessandro Aiuti, Alessandra Fantauzzi, Marcello Pinti, Andrea Cossarizza, Fernando Aiuti

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.

Original language	English
Pages (from-to)	1335-1337
Number of pages	3
Journal	AIDS (London, England)
Volume	18
Issue number	9
DOIs	https://doi.org/10.1097/00002030-200406180-00013
Publication status	Published - Jun 18 2004

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1097/00002030-200406180-00013

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Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy. / Isgrò, Antonella; Mezzaroma, Ivano; Aiuti, Alessandro; Fantauzzi, Alessandra; Pinti, Marcello; Cossarizza, Andrea; Aiuti, Fernando.

In: AIDS (London, England), Vol. 18, No. 9, 18.06.2004, p. 1335-1337.

Research output: Contribution to journal › Article › peer-review

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AU - Fantauzzi, Alessandra

AU - Pinti, Marcello

AU - Cossarizza, Andrea

AU - Aiuti, Fernando

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Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy

Abstract

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