Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy

Antonella Isgrò, Ivano Mezzaroma, Alessandro Aiuti, Alessandra Fantauzzi, Marcello Pinti, Andrea Cossarizza, Fernando Aiuti

Research output: Contribution to journalArticlepeer-review

Abstract

Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-I-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-α levels and the amelioration of clonogenic parameters.

Original languageEnglish
Pages (from-to)1335-1337
Number of pages3
JournalAIDS (London, England)
Volume18
Issue number9
DOIs
Publication statusPublished - Jun 18 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy'. Together they form a unique fingerprint.

Cite this