Decreased bacterial adhesion to surface-treated titanium

B. Del Curto, M. F. Brunella, C. Giordano, M. P. Pedeferri, V. Valtulina, L. Visai, Alberto Cigada

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Osteointegrative dental implants are widely used in implantology for their well-known excellent performance once implanted in the host. Remarkable bacterial colonization along the transgingival region may result in a progressive loss of adhesion at gum-implant interface and an increase of the bone area exposed to pathogens. This phenomenon may negatively effect the osteointegration process and cause, in the most severe cases, implant failure. The presence of bacteria at implant site affect the growth of new bone tissue and consequently, the achievement of a mechanically stable bone-implant interface, key parameters for a suitable implant osteointegration. In the present work, a novel surface treatment has been developed and optimized in order to convert the amorphous titanium oxide in a crystalline layer enriched in anatase capable of providing not only antibacterial properties but also of stimulating the precipitation of apatite when placed in simulated body fluid. The collected data have shown that the tested treatment results in a crystalline anatase-type titanium oxide layer able to provide a remarkable decrease in bacterial attachment without negatively effecting cell metabolic activity. In conclusion, the surface modification treatment analyzed in the present study might be an elegant way to reduce the risk of bacterial adhesion and increase the lifetime of the transgingival component in the osteointegrated dental implant.

Original languageEnglish
Pages (from-to)718-730
Number of pages13
JournalInternational Journal of Artificial Organs
Volume28
Issue number7
Publication statusPublished - Jul 2005

Fingerprint

Bacterial Adhesion
Titanium
Dental prostheses
Bone
Adhesion
Titanium oxides
Titanium dioxide
Dental Implants
Surface treatment
Crystalline materials
Body fluids
Apatite
Pathogens
Apatites
Bacteria
Gingiva
Body Fluids
Tissue
Bone and Bones
titanium dioxide

Keywords

  • Anatase
  • Bacterial adhesion
  • In vitro biological response
  • Osteointegration
  • Titanium

ASJC Scopus subject areas

  • Biophysics

Cite this

Del Curto, B., Brunella, M. F., Giordano, C., Pedeferri, M. P., Valtulina, V., Visai, L., & Cigada, A. (2005). Decreased bacterial adhesion to surface-treated titanium. International Journal of Artificial Organs, 28(7), 718-730.

Decreased bacterial adhesion to surface-treated titanium. / Del Curto, B.; Brunella, M. F.; Giordano, C.; Pedeferri, M. P.; Valtulina, V.; Visai, L.; Cigada, Alberto.

In: International Journal of Artificial Organs, Vol. 28, No. 7, 07.2005, p. 718-730.

Research output: Contribution to journalArticle

Del Curto, B, Brunella, MF, Giordano, C, Pedeferri, MP, Valtulina, V, Visai, L & Cigada, A 2005, 'Decreased bacterial adhesion to surface-treated titanium', International Journal of Artificial Organs, vol. 28, no. 7, pp. 718-730.
Del Curto B, Brunella MF, Giordano C, Pedeferri MP, Valtulina V, Visai L et al. Decreased bacterial adhesion to surface-treated titanium. International Journal of Artificial Organs. 2005 Jul;28(7):718-730.
Del Curto, B. ; Brunella, M. F. ; Giordano, C. ; Pedeferri, M. P. ; Valtulina, V. ; Visai, L. ; Cigada, Alberto. / Decreased bacterial adhesion to surface-treated titanium. In: International Journal of Artificial Organs. 2005 ; Vol. 28, No. 7. pp. 718-730.
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