Decreased cardiopulmonary reflexes with aging in normotensive humans

J. Cleroux, C. Giannattasio, G. Bolla, C. Cuspidi, G. Grassi, C. Mazzola, L. Sampieri, G. Seravalle, M. Valsecchi, G. Mancia

Research output: Contribution to journalArticle

Abstract

Arterial baroreflex is impaired in the normotensive elderly. However, no information is available on the effects of aging on another major reflex mechanism of cardiovascular control, i.e., cardiopulmonary reflex. Three groups of normotensive subjects divided according to age were evaluated during leg raising, which increased central venous pressure, and during lower body negative pressures, which reduced central venous pressure without altering blood pressure and heart rate. These maneuvers stimulated and deactivated cardiopulmonary receptors with only little involvement of arterial baroreceptors. During lower body negative pressures, central venous pressure decreased similarly in three groups, but reflex increases in forearm vascular resistance, plasma norepinephrine, and plasma renin activity were smaller in elderly than in middle-aged and young subjects. Furthermore, during leg raising, comparable increases in central venous pressure caused reflex vascular and humoral responses that were smaller in elderly than in middle-aged and young subjects. Elderly subjects had smaller changes in left ventricular diameter in response to changes in central venous pressure. Blood pressure and vascular responses to cold pressor test were similar in the three groups, excluding a hyporeactivity of older subjects to neural stimuli. Thus aging is associated with an impairment of the cardiopulmonary reflex. This may originate from an impaired ability of cardiac receptors to sense alterations in central blood volume because of an age-dependent reduction in cardiac compliance.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume257
Issue number3
Publication statusPublished - 1989

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Abnormal Reflexes
Central Venous Pressure
Reflex
Lower Body Negative Pressure
Blood Vessels
Leg
Blood Pressure
Pressoreceptors
Aptitude
Baroreflex
Blood Volume
Renin
Forearm
Vascular Resistance
Compliance
Norepinephrine
Heart Rate

ASJC Scopus subject areas

  • Physiology

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Decreased cardiopulmonary reflexes with aging in normotensive humans. / Cleroux, J.; Giannattasio, C.; Bolla, G.; Cuspidi, C.; Grassi, G.; Mazzola, C.; Sampieri, L.; Seravalle, G.; Valsecchi, M.; Mancia, G.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 257, No. 3, 1989.

Research output: Contribution to journalArticle

Cleroux, J, Giannattasio, C, Bolla, G, Cuspidi, C, Grassi, G, Mazzola, C, Sampieri, L, Seravalle, G, Valsecchi, M & Mancia, G 1989, 'Decreased cardiopulmonary reflexes with aging in normotensive humans', American Journal of Physiology - Heart and Circulatory Physiology, vol. 257, no. 3.
Cleroux, J. ; Giannattasio, C. ; Bolla, G. ; Cuspidi, C. ; Grassi, G. ; Mazzola, C. ; Sampieri, L. ; Seravalle, G. ; Valsecchi, M. ; Mancia, G. / Decreased cardiopulmonary reflexes with aging in normotensive humans. In: American Journal of Physiology - Heart and Circulatory Physiology. 1989 ; Vol. 257, No. 3.
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