Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency

Annalisa Marcuzzi, Giuliana Decorti, Alessandra Pontillo, Alessandro Ventura, Alberto Tommasini

Research output: Contribution to journalArticle

Abstract

Objective The aim of this study was to evaluate, in a mouse model of mevalonate kinase deficiency (MKD), the possible link between inflammatory symptoms and serum cholesterol levels. Materials and methods Balb/c mice were treated with alendronate and bacterial muramyl dipeptide. Body temperature, interleukin-1Β (IL-1Β) secretion and serum cholesterol levels were measured. Results An increased production of the pro-inflammatory cytokine IL-1Β (p

Original languageEnglish
Pages (from-to)335-338
Number of pages4
JournalInflammation Research
Volume59
Issue number5
DOIs
Publication statusPublished - May 2010

Fingerprint

Mevalonate Kinase Deficiency
Terpenes
Interleukin-1
Anti-Inflammatory Agents
Cholesterol
Acetylmuramyl-Alanyl-Isoglutamine
Inflammation
Alendronate
Body Temperature
Serum
Cytokines

Keywords

  • Cholesterol
  • IL-1Β
  • Inflammation
  • Mevalonate kinase deficiency
  • Temperature

ASJC Scopus subject areas

  • Pharmacology
  • Immunology

Cite this

Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency. / Marcuzzi, Annalisa; Decorti, Giuliana; Pontillo, Alessandra; Ventura, Alessandro; Tommasini, Alberto.

In: Inflammation Research, Vol. 59, No. 5, 05.2010, p. 335-338.

Research output: Contribution to journalArticle

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AU - Ventura, Alessandro

AU - Tommasini, Alberto

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AB - Objective The aim of this study was to evaluate, in a mouse model of mevalonate kinase deficiency (MKD), the possible link between inflammatory symptoms and serum cholesterol levels. Materials and methods Balb/c mice were treated with alendronate and bacterial muramyl dipeptide. Body temperature, interleukin-1Β (IL-1Β) secretion and serum cholesterol levels were measured. Results An increased production of the pro-inflammatory cytokine IL-1Β (p

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