TY - JOUR
T1 - Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency
AU - Marcuzzi, Annalisa
AU - Decorti, Giuliana
AU - Pontillo, Alessandra
AU - Ventura, Alessandro
AU - Tommasini, Alberto
PY - 2010/5
Y1 - 2010/5
N2 - Objective The aim of this study was to evaluate, in a mouse model of mevalonate kinase deficiency (MKD), the possible link between inflammatory symptoms and serum cholesterol levels. Materials and methods Balb/c mice were treated with alendronate and bacterial muramyl dipeptide. Body temperature, interleukin-1Β (IL-1Β) secretion and serum cholesterol levels were measured. Results An increased production of the pro-inflammatory cytokine IL-1Β (p
AB - Objective The aim of this study was to evaluate, in a mouse model of mevalonate kinase deficiency (MKD), the possible link between inflammatory symptoms and serum cholesterol levels. Materials and methods Balb/c mice were treated with alendronate and bacterial muramyl dipeptide. Body temperature, interleukin-1Β (IL-1Β) secretion and serum cholesterol levels were measured. Results An increased production of the pro-inflammatory cytokine IL-1Β (p
KW - Cholesterol
KW - IL-1Β
KW - Inflammation
KW - Mevalonate kinase deficiency
KW - Temperature
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U2 - 10.1007/s00011-010-0168-6
DO - 10.1007/s00011-010-0168-6
M3 - Article
C2 - 20174853
AN - SCOPUS:77953364021
VL - 59
SP - 335
EP - 338
JO - Inflammation Research
JF - Inflammation Research
SN - 1023-3830
IS - 5
ER -