Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency

Annalisa Marcuzzi; Giuliana Decorti; Alessandra Pontillo; Alessandro Ventura; Alberto Tommasini

doi:10.1007/s00011-010-0168-6

Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency

Annalisa Marcuzzi, Giuliana Decorti, Alessandra Pontillo, Alessandro Ventura, Alberto Tommasini

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article › peer-review

Abstract

Objective The aim of this study was to evaluate, in a mouse model of mevalonate kinase deficiency (MKD), the possible link between inflammatory symptoms and serum cholesterol levels. Materials and methods Balb/c mice were treated with alendronate and bacterial muramyl dipeptide. Body temperature, interleukin-1Β (IL-1Β) secretion and serum cholesterol levels were measured. Results An increased production of the pro-inflammatory cytokine IL-1Β (p

Original language	English
Pages (from-to)	335-338
Number of pages	4
Journal	Inflammation Research
Volume	59
Issue number	5
DOIs	https://doi.org/10.1007/s00011-010-0168-6
Publication status	Published - May 2010

Keywords

Cholesterol
IL-1Β
Inflammation
Mevalonate kinase deficiency
Temperature

ASJC Scopus subject areas

Pharmacology
Immunology

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Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency. / Marcuzzi, Annalisa; Decorti, Giuliana; Pontillo, Alessandra; Ventura, Alessandro; Tommasini, Alberto.

In: Inflammation Research, Vol. 59, No. 5, 05.2010, p. 335-338.

Research output: Contribution to journal › Article › peer-review

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AU - Ventura, Alessandro

AU - Tommasini, Alberto

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