Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency

Annalisa Marcuzzi, Giuliana Decorti, Alessandra Pontillo, Alessandro Ventura, Alberto Tommasini

Research output: Contribution to journal › Article

Abstract

Objective The aim of this study was to evaluate, in a mouse model of mevalonate kinase deficiency (MKD), the possible link between inflammatory symptoms and serum cholesterol levels. Materials and methods Balb/c mice were treated with alendronate and bacterial muramyl dipeptide. Body temperature, interleukin-1Β (IL-1Β) secretion and serum cholesterol levels were measured. Results An increased production of the pro-inflammatory cytokine IL-1Β (p

Original languageEnglish
Pages (from-to)335-338
Number of pages4
JournalInflammation Research
Volume59
Issue number5
DOIs
Publication statusPublished - May 2010

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Mevalonate Kinase Deficiency
Terpenes
Interleukin-1
Anti-Inflammatory Agents
Cholesterol
Acetylmuramyl-Alanyl-Isoglutamine
Inflammation
Alendronate
Body Temperature
Serum
Cytokines

Keywords

  • Cholesterol
  • IL-1Β
  • Inflammation
  • Mevalonate kinase deficiency
  • Temperature

ASJC Scopus subject areas

  • Pharmacology
  • Immunology

Cite this

Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency. / Marcuzzi, Annalisa; Decorti, Giuliana; Pontillo, Alessandra; Ventura, Alessandro; Tommasini, Alberto.

In: Inflammation Research, Vol. 59, No. 5, 05.2010, p. 335-338.

Research output: Contribution to journal › Article

Marcuzzi, A, Decorti, G, Pontillo, A, Ventura, A & Tommasini, A 2010, 'Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency', Inflammation Research, vol. 59, no. 5, pp. 335-338. https://doi.org/10.1007/s00011-010-0168-6
Marcuzzi A, Decorti G, Pontillo A, Ventura A, Tommasini A. Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency. Inflammation Research. 2010 May;59(5):335-338. https://doi.org/10.1007/s00011-010-0168-6
Marcuzzi, Annalisa ; Decorti, Giuliana ; Pontillo, Alessandra ; Ventura, Alessandro ; Tommasini, Alberto. / Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency. In: Inflammation Research. 2010 ; Vol. 59, No. 5. pp. 335-338.
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