Decreased CSF levels of ß-amyloid in patients with cortical superficial siderosis

Cihan Catak, Marialuisa Zedde, Rainer Malik, Daniel Janowitz, Vivian Soric, Anna Seegerer, Alexander Krebs, Marco Düring, Christian Opherk, Jennifer Linn, Frank A. Wollenweber

Research output: Contribution to journalArticle

Abstract

Background: Cortical superficial siderosis (cSS) represents a key neuroimaging marker of cerebral amyloid angiopathy (CAA) that is associated with intracranial hemorrhages and cognitive impairment. Nevertheless, the association between cSS and core cerebrospinal fluid (CSF) biomarkers for dementia remain unclear. Methods: One hundred and one patients with probable (79%, 80/101) or possible (21%, 21/101) CAA according to the modified Boston criteria and mild cognitive impairment according to Petersen criteria were prospectively included between 2011 and 2016. CSF analyses of ß-amyloid 42, ß-amyloid 40, total tau and phosphorylated tau were performed using sandwich-type enzyme-linked immunosorbent-assay. All patients received MRI and Mini-Mental-State Examination (MMSE). Logistic regression analysis was used to adjust for possible confounders. Results: cSS was present in 61% (62/101). Of those, 53% (33/62) had disseminated cSS and 47% (29/62) focal cSS. ß-amyloid 42 was lower in patients with cSS than in patients without cSS (OR 0.2; 95% CI 0.08–0.6; p = 0.0052) and lower in patients with disseminated cSS than in those with focal cSS (OR 0.02; 95% CI 0.003–0.2; p = 0.00057). Presence of cSS had no association with regard to ß-amyloid 40, total tau and phosphorylated tau. Conclusions: Our results demonstrate that the presence and extent of cSS are associated with reduced CSF ß-amyloid 42 levels. Further studies are needed to investigate the underlying mechanisms of this association.

Original languageEnglish
Article number439
JournalFrontiers in Neurology
Volume10
Issue numberAPR
DOIs
Publication statusPublished - Jan 1 2019
Externally publishedYes

Fingerprint

Siderosis
Amyloid
Cerebrospinal Fluid
Cerebral Amyloid Angiopathy
Intracranial Hemorrhages
Neuroimaging
Dementia

Keywords

  • Cerebral amyloid angiopathy
  • Cerebral microbleeds
  • Cerebrospinal fluid
  • Cortical superficial siderosis
  • Neuroimaging

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Catak, C., Zedde, M., Malik, R., Janowitz, D., Soric, V., Seegerer, A., ... Wollenweber, F. A. (2019). Decreased CSF levels of ß-amyloid in patients with cortical superficial siderosis. Frontiers in Neurology, 10(APR), [439]. https://doi.org/10.3389/fneur.2019.00439

Decreased CSF levels of ß-amyloid in patients with cortical superficial siderosis. / Catak, Cihan; Zedde, Marialuisa; Malik, Rainer; Janowitz, Daniel; Soric, Vivian; Seegerer, Anna; Krebs, Alexander; Düring, Marco; Opherk, Christian; Linn, Jennifer; Wollenweber, Frank A.

In: Frontiers in Neurology, Vol. 10, No. APR, 439, 01.01.2019.

Research output: Contribution to journalArticle

Catak, C, Zedde, M, Malik, R, Janowitz, D, Soric, V, Seegerer, A, Krebs, A, Düring, M, Opherk, C, Linn, J & Wollenweber, FA 2019, 'Decreased CSF levels of ß-amyloid in patients with cortical superficial siderosis', Frontiers in Neurology, vol. 10, no. APR, 439. https://doi.org/10.3389/fneur.2019.00439
Catak, Cihan ; Zedde, Marialuisa ; Malik, Rainer ; Janowitz, Daniel ; Soric, Vivian ; Seegerer, Anna ; Krebs, Alexander ; Düring, Marco ; Opherk, Christian ; Linn, Jennifer ; Wollenweber, Frank A. / Decreased CSF levels of ß-amyloid in patients with cortical superficial siderosis. In: Frontiers in Neurology. 2019 ; Vol. 10, No. APR.
@article{3427e29760514ca4a050ebf30e25acfa,
title = "Decreased CSF levels of {\ss}-amyloid in patients with cortical superficial siderosis",
abstract = "Background: Cortical superficial siderosis (cSS) represents a key neuroimaging marker of cerebral amyloid angiopathy (CAA) that is associated with intracranial hemorrhages and cognitive impairment. Nevertheless, the association between cSS and core cerebrospinal fluid (CSF) biomarkers for dementia remain unclear. Methods: One hundred and one patients with probable (79{\%}, 80/101) or possible (21{\%}, 21/101) CAA according to the modified Boston criteria and mild cognitive impairment according to Petersen criteria were prospectively included between 2011 and 2016. CSF analyses of {\ss}-amyloid 42, {\ss}-amyloid 40, total tau and phosphorylated tau were performed using sandwich-type enzyme-linked immunosorbent-assay. All patients received MRI and Mini-Mental-State Examination (MMSE). Logistic regression analysis was used to adjust for possible confounders. Results: cSS was present in 61{\%} (62/101). Of those, 53{\%} (33/62) had disseminated cSS and 47{\%} (29/62) focal cSS. {\ss}-amyloid 42 was lower in patients with cSS than in patients without cSS (OR 0.2; 95{\%} CI 0.08–0.6; p = 0.0052) and lower in patients with disseminated cSS than in those with focal cSS (OR 0.02; 95{\%} CI 0.003–0.2; p = 0.00057). Presence of cSS had no association with regard to {\ss}-amyloid 40, total tau and phosphorylated tau. Conclusions: Our results demonstrate that the presence and extent of cSS are associated with reduced CSF {\ss}-amyloid 42 levels. Further studies are needed to investigate the underlying mechanisms of this association.",
keywords = "Cerebral amyloid angiopathy, Cerebral microbleeds, Cerebrospinal fluid, Cortical superficial siderosis, Neuroimaging",
author = "Cihan Catak and Marialuisa Zedde and Rainer Malik and Daniel Janowitz and Vivian Soric and Anna Seegerer and Alexander Krebs and Marco D{\"u}ring and Christian Opherk and Jennifer Linn and Wollenweber, {Frank A.}",
year = "2019",
month = "1",
day = "1",
doi = "10.3389/fneur.2019.00439",
language = "English",
volume = "10",
journal = "Frontiers in Neurology",
issn = "1664-2295",
publisher = "Frontiers Research Foundation",
number = "APR",

}

TY - JOUR

T1 - Decreased CSF levels of ß-amyloid in patients with cortical superficial siderosis

AU - Catak, Cihan

AU - Zedde, Marialuisa

AU - Malik, Rainer

AU - Janowitz, Daniel

AU - Soric, Vivian

AU - Seegerer, Anna

AU - Krebs, Alexander

AU - Düring, Marco

AU - Opherk, Christian

AU - Linn, Jennifer

AU - Wollenweber, Frank A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Cortical superficial siderosis (cSS) represents a key neuroimaging marker of cerebral amyloid angiopathy (CAA) that is associated with intracranial hemorrhages and cognitive impairment. Nevertheless, the association between cSS and core cerebrospinal fluid (CSF) biomarkers for dementia remain unclear. Methods: One hundred and one patients with probable (79%, 80/101) or possible (21%, 21/101) CAA according to the modified Boston criteria and mild cognitive impairment according to Petersen criteria were prospectively included between 2011 and 2016. CSF analyses of ß-amyloid 42, ß-amyloid 40, total tau and phosphorylated tau were performed using sandwich-type enzyme-linked immunosorbent-assay. All patients received MRI and Mini-Mental-State Examination (MMSE). Logistic regression analysis was used to adjust for possible confounders. Results: cSS was present in 61% (62/101). Of those, 53% (33/62) had disseminated cSS and 47% (29/62) focal cSS. ß-amyloid 42 was lower in patients with cSS than in patients without cSS (OR 0.2; 95% CI 0.08–0.6; p = 0.0052) and lower in patients with disseminated cSS than in those with focal cSS (OR 0.02; 95% CI 0.003–0.2; p = 0.00057). Presence of cSS had no association with regard to ß-amyloid 40, total tau and phosphorylated tau. Conclusions: Our results demonstrate that the presence and extent of cSS are associated with reduced CSF ß-amyloid 42 levels. Further studies are needed to investigate the underlying mechanisms of this association.

AB - Background: Cortical superficial siderosis (cSS) represents a key neuroimaging marker of cerebral amyloid angiopathy (CAA) that is associated with intracranial hemorrhages and cognitive impairment. Nevertheless, the association between cSS and core cerebrospinal fluid (CSF) biomarkers for dementia remain unclear. Methods: One hundred and one patients with probable (79%, 80/101) or possible (21%, 21/101) CAA according to the modified Boston criteria and mild cognitive impairment according to Petersen criteria were prospectively included between 2011 and 2016. CSF analyses of ß-amyloid 42, ß-amyloid 40, total tau and phosphorylated tau were performed using sandwich-type enzyme-linked immunosorbent-assay. All patients received MRI and Mini-Mental-State Examination (MMSE). Logistic regression analysis was used to adjust for possible confounders. Results: cSS was present in 61% (62/101). Of those, 53% (33/62) had disseminated cSS and 47% (29/62) focal cSS. ß-amyloid 42 was lower in patients with cSS than in patients without cSS (OR 0.2; 95% CI 0.08–0.6; p = 0.0052) and lower in patients with disseminated cSS than in those with focal cSS (OR 0.02; 95% CI 0.003–0.2; p = 0.00057). Presence of cSS had no association with regard to ß-amyloid 40, total tau and phosphorylated tau. Conclusions: Our results demonstrate that the presence and extent of cSS are associated with reduced CSF ß-amyloid 42 levels. Further studies are needed to investigate the underlying mechanisms of this association.

KW - Cerebral amyloid angiopathy

KW - Cerebral microbleeds

KW - Cerebrospinal fluid

KW - Cortical superficial siderosis

KW - Neuroimaging

UR - http://www.scopus.com/inward/record.url?scp=85067861793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067861793&partnerID=8YFLogxK

U2 - 10.3389/fneur.2019.00439

DO - 10.3389/fneur.2019.00439

M3 - Article

AN - SCOPUS:85067861793

VL - 10

JO - Frontiers in Neurology

JF - Frontiers in Neurology

SN - 1664-2295

IS - APR

M1 - 439

ER -