Decreased density of lymphocyte benzodiazepine receptors in drug- resistant epileptic patients

Carlo Ferrarese, Rachele Tortorella, Graziella Bogliun, Ettore Beghi, Tiziana Cogliati, Chiara Zoia, Davide Passoni, Lodovico Frattola

Research output: Contribution to journalArticlepeer-review

Abstract

Peripheral benzodiazepine receptors (PBR) may have a role in epilepsy and in mediating antiepileptic drug effects. Since PBR in blood mononuclear cells may be acted on by anticonvulsant drugs, we investigated possible modifications of these receptors in newly diagnosed patients, before and after antiepileptic treatment and in drug-resistant epileptic patients. A significantly lower receptor density, with no difference in affinity, was observed in drug-resistant patients, compared to newly diagnosed patients and to normal age-related controls. We suggest the possible use of PBR as a peripheral marker of drug response.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalEpilepsy Research
Volume27
Issue number3
DOIs
Publication statusPublished - Jun 1997

Keywords

  • Anticonvulsant drugs
  • Drug resistance
  • Epilepsy
  • Lymphocytes
  • Peripheral benzodiazepine receptors

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

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