Decreased fibrinolytic activity in juvenile chronic arthritis

Luciana Mussoni, Giuseppe Pintucci, Geremia Romano, Fabrizio De Benedetti, Margherita Massa, Alberto Martini

Research output: Contribution to journalArticlepeer-review


The basal fibrinolytic activity in 17 children with active juvenile chronic arthritis (CA) was investigated. It was found that patients with JCA, and particularly those with the systemic form, show decreased plasma fibrinolytic activity and a marked increase in plasminogen activator inhibitor. Additionally, it was found that patients with systemic JCA, but not those with the polyarticular or pauciarticular form, have increased circulating levels of tissue-type plasminogen activator, an endothelial cell protein, suggesting possible endothelial cell participation in systemic JCA.

Original languageEnglish
Pages (from-to)973-975
Number of pages3
JournalAnnals of the Rheumatic Diseases
Issue number12
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Immunology
  • Rheumatology


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