Decreased half life of cyclophosphamide in patients under continual treatment

Maurizio D'Incalci, Giorgio Bolis, Terenzio Facchinetti, Costantino Mangioni, Luciano Morasca, Paolo Morazzoni, Mario Salmona

Research output: Contribution to journalArticlepeer-review


Plasma levels of cyclophosphamide (Cy) were measured in 16 cancer patients receiving 100 mg/day of Cy for over 1 yr. Oral and intravenous administrations gave similar AUC values, confirming that intestinal absorption is almost complete. When pharmacokinetics obtained at the first course of therapy were compared with pharmacokinetics measured after more than 6 months continual treatment, T 1 2 and Vd appeared significantly lower in the second population despite broad variability among patients.

Original languageEnglish
Pages (from-to)7-10
Number of pages4
JournalEuropean Journal of Cancer (1965)
Issue number1
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Oncology


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