Decreased half life of cyclophosphamide in patients under continual treatment

Maurizio D'Incalci; Giorgio Bolis; Terenzio Facchinetti; Costantino Mangioni; Luciano Morasca; Paolo Morazzoni; Mario Salmona

doi:10.1016/0014-2964(79)90198-1

Decreased half life of cyclophosphamide in patients under continual treatment

Maurizio D'Incalci, Giorgio Bolis, Terenzio Facchinetti, Costantino Mangioni, Luciano Morasca, Paolo Morazzoni, Mario Salmona

Research output: Contribution to journal › Article

Abstract

Plasma levels of cyclophosphamide (Cy) were measured in 16 cancer patients receiving 100 mg/day of Cy for over 1 yr. Oral and intravenous administrations gave similar AUC values, confirming that intestinal absorption is almost complete. When pharmacokinetics obtained at the first course of therapy were compared with pharmacokinetics measured after more than 6 months continual treatment, T 1 2 and Vd appeared significantly lower in the second population despite broad variability among patients.

Original language	English
Pages (from-to)	7-10
Number of pages	4
Journal	European Journal of Cancer (1965)
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/0014-2964(79)90198-1
Publication status	Published - 1979

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ASJC Scopus subject areas

Oncology

Cite this

D'Incalci, M., Bolis, G., Facchinetti, T., Mangioni, C., Morasca, L., Morazzoni, P., & Salmona, M. (1979). Decreased half life of cyclophosphamide in patients under continual treatment. European Journal of Cancer (1965), 15(1), 7-10. https://doi.org/10.1016/0014-2964(79)90198-1

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AU - Morazzoni, Paolo

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10.1016/0014-2964(79)90198-1