TY - JOUR
T1 - Decreased half life of cyclophosphamide in patients under continual treatment
AU - D'Incalci, Maurizio
AU - Bolis, Giorgio
AU - Facchinetti, Terenzio
AU - Mangioni, Costantino
AU - Morasca, Luciano
AU - Morazzoni, Paolo
AU - Salmona, Mario
PY - 1979
Y1 - 1979
N2 - Plasma levels of cyclophosphamide (Cy) were measured in 16 cancer patients receiving 100 mg/day of Cy for over 1 yr. Oral and intravenous administrations gave similar AUC values, confirming that intestinal absorption is almost complete. When pharmacokinetics obtained at the first course of therapy were compared with pharmacokinetics measured after more than 6 months continual treatment, T 1 2 and Vd appeared significantly lower in the second population despite broad variability among patients.
AB - Plasma levels of cyclophosphamide (Cy) were measured in 16 cancer patients receiving 100 mg/day of Cy for over 1 yr. Oral and intravenous administrations gave similar AUC values, confirming that intestinal absorption is almost complete. When pharmacokinetics obtained at the first course of therapy were compared with pharmacokinetics measured after more than 6 months continual treatment, T 1 2 and Vd appeared significantly lower in the second population despite broad variability among patients.
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U2 - 10.1016/0014-2964(79)90198-1
DO - 10.1016/0014-2964(79)90198-1
M3 - Article
C2 - 421718
AN - SCOPUS:0018772548
VL - 15
SP - 7
EP - 10
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0014-2964
IS - 1
ER -