Abstract
Plasma levels of cyclophosphamide (Cy) were measured in 16 cancer patients receiving 100 mg/day of Cy for over 1 yr. Oral and intravenous administrations gave similar AUC values, confirming that intestinal absorption is almost complete. When pharmacokinetics obtained at the first course of therapy were compared with pharmacokinetics measured after more than 6 months continual treatment, T 1 2 and Vd appeared significantly lower in the second population despite broad variability among patients.
| Original language | English |
|---|---|
| Pages (from-to) | 7-10 |
| Number of pages | 4 |
| Journal | European Journal of Cancer (1965) |
| Volume | 15 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1979 |
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ASJC Scopus subject areas
- Oncology
Cite this
Decreased half life of cyclophosphamide in patients under continual treatment. / D'Incalci, Maurizio; Bolis, Giorgio; Facchinetti, Terenzio; Mangioni, Costantino; Morasca, Luciano; Morazzoni, Paolo; Salmona, Mario.
In: European Journal of Cancer (1965), Vol. 15, No. 1, 1979, p. 7-10.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Decreased half life of cyclophosphamide in patients under continual treatment
AU - D'Incalci, Maurizio
AU - Bolis, Giorgio
AU - Facchinetti, Terenzio
AU - Mangioni, Costantino
AU - Morasca, Luciano
AU - Morazzoni, Paolo
AU - Salmona, Mario
PY - 1979
Y1 - 1979
N2 - Plasma levels of cyclophosphamide (Cy) were measured in 16 cancer patients receiving 100 mg/day of Cy for over 1 yr. Oral and intravenous administrations gave similar AUC values, confirming that intestinal absorption is almost complete. When pharmacokinetics obtained at the first course of therapy were compared with pharmacokinetics measured after more than 6 months continual treatment, T 1 2 and Vd appeared significantly lower in the second population despite broad variability among patients.
AB - Plasma levels of cyclophosphamide (Cy) were measured in 16 cancer patients receiving 100 mg/day of Cy for over 1 yr. Oral and intravenous administrations gave similar AUC values, confirming that intestinal absorption is almost complete. When pharmacokinetics obtained at the first course of therapy were compared with pharmacokinetics measured after more than 6 months continual treatment, T 1 2 and Vd appeared significantly lower in the second population despite broad variability among patients.
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U2 - 10.1016/0014-2964(79)90198-1
DO - 10.1016/0014-2964(79)90198-1
M3 - Article
VL - 15
SP - 7
EP - 10
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0014-2964
IS - 1
ER -