Abstract
Autoregressive spectral analysis of heart rate variability (HRV) was performed in 29 patients with amyotrophic lateral sclerosis (ALS) and 33 age- matched healthy subjects to evaluate the involvement of the autonomic nervous system. HRV analysis provides a means to recognize low (LF) and high (HF) frequency components, respectively mediated by sympathetic and parasympathetic heart control. An increase in the mean heart rate at rest (P <0.001), a decrease in standard deviation of R-R interval as well as in PNN50 (P <0.001), and an increase in the LF/HF component ratio (P <0.01) were found in the ALS patients, indicating a vigil-sympathetic imbalance. These alterations were not related to the clinical features and to the duration of the disease. Our results suggest a subclinical involvement of the autonomic nervous system in ALS, particularly affecting parasympathetic cardiovascular control.
| Original language | English |
|---|---|
| Pages (from-to) | 1225-1231 |
| Number of pages | 7 |
| Journal | Muscle and Nerve |
| Volume | 18 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 1995 |
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Keywords
- amyotrophic lateral sclerosis
- autonomic nervous system
- dysautonomia
- heart rate variability
- spectral analysis
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Decreased heart rate variability in amyotrophic lateral sclerosis. / Pisano, F.; Miscio, G.; Mazzuero, G.; Lanfranchi, P.; Colombo, R.; Pinelli, P.
In: Muscle and Nerve, Vol. 18, No. 11, 1995, p. 1225-1231.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Decreased heart rate variability in amyotrophic lateral sclerosis
AU - Pisano, F.
AU - Miscio, G.
AU - Mazzuero, G.
AU - Lanfranchi, P.
AU - Colombo, R.
AU - Pinelli, P.
PY - 1995
Y1 - 1995
N2 - Autoregressive spectral analysis of heart rate variability (HRV) was performed in 29 patients with amyotrophic lateral sclerosis (ALS) and 33 age- matched healthy subjects to evaluate the involvement of the autonomic nervous system. HRV analysis provides a means to recognize low (LF) and high (HF) frequency components, respectively mediated by sympathetic and parasympathetic heart control. An increase in the mean heart rate at rest (P <0.001), a decrease in standard deviation of R-R interval as well as in PNN50 (P <0.001), and an increase in the LF/HF component ratio (P <0.01) were found in the ALS patients, indicating a vigil-sympathetic imbalance. These alterations were not related to the clinical features and to the duration of the disease. Our results suggest a subclinical involvement of the autonomic nervous system in ALS, particularly affecting parasympathetic cardiovascular control.
AB - Autoregressive spectral analysis of heart rate variability (HRV) was performed in 29 patients with amyotrophic lateral sclerosis (ALS) and 33 age- matched healthy subjects to evaluate the involvement of the autonomic nervous system. HRV analysis provides a means to recognize low (LF) and high (HF) frequency components, respectively mediated by sympathetic and parasympathetic heart control. An increase in the mean heart rate at rest (P <0.001), a decrease in standard deviation of R-R interval as well as in PNN50 (P <0.001), and an increase in the LF/HF component ratio (P <0.01) were found in the ALS patients, indicating a vigil-sympathetic imbalance. These alterations were not related to the clinical features and to the duration of the disease. Our results suggest a subclinical involvement of the autonomic nervous system in ALS, particularly affecting parasympathetic cardiovascular control.
KW - amyotrophic lateral sclerosis
KW - autonomic nervous system
KW - dysautonomia
KW - heart rate variability
KW - spectral analysis
UR - http://www.scopus.com/inward/record.url?scp=0028809835&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028809835&partnerID=8YFLogxK
U2 - 10.1002/mus.880181103
DO - 10.1002/mus.880181103
M3 - Article
C2 - 7565918
AN - SCOPUS:0028809835
VL - 18
SP - 1225
EP - 1231
JO - Muscle and Nerve
JF - Muscle and Nerve
SN - 0148-639X
IS - 11
ER -