Decreased heart rate variability in patients with chronic obstructive pulmonary disease

M. Volterrani, S. Scalvini, G. Mazzuero, P. Lanfranchi, R. Colombo, A. L. Clark, G. Levi

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate possible autonomic nervous system (ANS) dysfunction in patients with chronic obstructive pulmonary disease (COPD) in the absence of any hypoxic neuronal damage, we studied 31 patients with COPD patients aged 31 to 68 years (55±10) and 32 age-matched healthy subjects (control). Respiratory function in the patients was as follows: FEV1=52±8 percent; PaO2=71±14 mm Hg; and PaCO2=40±10 mm Hg. The ANS was assessed by heart rate variability (HRV) in the time domain (SD of mean RR interval) and frequency domain (autoregressive spectral analysis recognizing low [LF] and high [HF] frequency components, vagal and sympathetic related, respectively). Patients and controls were evaluated at rest and during vagal (controlled breathing [CB]) and sympathetic (passive head-up tilt) maneuvers. Patients with COPD showed a depressed global HRV (rest SD=34±20 ms vs 45±15 ms, p

Original languageEnglish
Pages (from-to)1432-1437
Number of pages6
JournalChest
Volume106
Issue number5
Publication statusPublished - 1994

Keywords

  • autonomic nervous system
  • COPD
  • heart rate variability
  • power spectral analysis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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